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IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives

1
Institute of Anatomy, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic
2
Department of Stomatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12801 Prague, Czech Republic
3
BIOCEV, Biotechnology and Biomedicine Centre, Academy of Science and Charles University, 25250 Vestec, Czech Republic
4
Department of Dermatovenereology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editors: Lydie Izakovicova Holla and Yasusei Kudo
Int. J. Mol. Sci. 2021, 22(20), 11027; https://doi.org/10.3390/ijms222011027
Received: 23 August 2021 / Revised: 25 September 2021 / Accepted: 29 September 2021 / Published: 13 October 2021
Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer. View Full-Text
Keywords: IL-6; head and neck cancer; cancer microenvironment; targeted therapy IL-6; head and neck cancer; cancer microenvironment; targeted therapy
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MDPI and ACS Style

Španko, M.; Strnadová, K.; Pavlíček, A.J.; Szabo, P.; Kodet, O.; Valach, J.; Dvořánková, B.; Smetana, K., Jr.; Lacina, L. IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives. Int. J. Mol. Sci. 2021, 22, 11027. https://doi.org/10.3390/ijms222011027

AMA Style

Španko M, Strnadová K, Pavlíček AJ, Szabo P, Kodet O, Valach J, Dvořánková B, Smetana K Jr., Lacina L. IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives. International Journal of Molecular Sciences. 2021; 22(20):11027. https://doi.org/10.3390/ijms222011027

Chicago/Turabian Style

Španko, Michal, Karolína Strnadová, Aleš J. Pavlíček, Pavol Szabo, Ondřej Kodet, Jaroslav Valach, Barbora Dvořánková, Karel Smetana Jr., and Lukáš Lacina. 2021. "IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives" International Journal of Molecular Sciences 22, no. 20: 11027. https://doi.org/10.3390/ijms222011027

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