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Review
Peer-Review Record

Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies

Int. J. Mol. Sci. 2021, 22(19), 10714; https://doi.org/10.3390/ijms221910714
by Xin-Xin Guan, Dong-Ning Rao, Yan-Zhe Liu, Yong Zhou and Hui-Hui Yang *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(19), 10714; https://doi.org/10.3390/ijms221910714
Submission received: 7 September 2021 / Revised: 26 September 2021 / Accepted: 27 September 2021 / Published: 3 October 2021
(This article belongs to the Section Molecular Immunology)

Round 1

Reviewer 1 Report

Authors have dicussed anti-fibrosis property of EETs in kindeys, heart, lung, and liver.

For mechansims as indicated in all 4 figures, authors show that EETs enter cells and activate a number of protective pathways. Authors failed to discuss the possibility that EETs can interact with EET receptor on plasma membrane.

Authors also failed to compare the efficacy of epoxy groups at different carbon (5-6, 8-9, 11-12, 14-15) on arachidonic acid.

Please add abbreviation of EETs in Introduction.

Please indicate Figure 1, 2, 3, and 4 in texts.

In Figure 1 legend, 'achieves' should be 'is achieved'. 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

I have found this review by Xin-Xin Guan and colleagues interesting and easy to follow. To make this review more reader-friendly, I suggest the authors including a table for each described fibrotic condition, summarising the beneficial effects (antiinflammatory) of EETs in these organs.

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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