Next Article in Journal
Transcriptome and Proteome Analysis Revealed Key Pathways Regulating Final Stage of Oocyte Maturation of the Turkey (Meleagris gallopavo)
Next Article in Special Issue
Differential Transcriptional Regulation of Polymorphic p53 Codon 72 in Metabolic Pathways
Previous Article in Journal
Investigation of the Epithelial to Mesenchymal Transition (EMT) Process in Equine Papillomavirus-2 (EcPV-2)-Positive Penile Squamous Cell Carcinomas
Previous Article in Special Issue
p53 Activation in Genetic Disorders: Different Routes to the Same Destination
Review

Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey

1
Institute of Mathematics and Scientific Computing, University of Graz, Heinrichstrasse 36, 8010 Graz, Austria
2
School of Mathematics and Statistics, Mathematical Institute, University of St Andrews, St Andrews KY16 9SS, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Alfonso Baldi
Int. J. Mol. Sci. 2021, 22(19), 10590; https://doi.org/10.3390/ijms221910590
Received: 1 September 2021 / Revised: 14 September 2021 / Accepted: 26 September 2021 / Published: 30 September 2021
(This article belongs to the Special Issue The Functional Landscape of p53)
No gene has garnered more interest than p53 since its discovery over 40 years ago. In the last two decades, thanks to seminal work from Uri Alon and Ghalit Lahav, p53 has defined a truly synergistic topic in the field of mathematical biology, with a rich body of research connecting mathematic endeavour with experimental design and data. In this review we survey and distill the extensive literature of mathematical models of p53. Specifically, we focus on models which seek to reproduce the oscillatory dynamics of p53 in response to DNA damage. We review the standard modelling approaches used in the field categorising them into three types: time delay models, spatial models and coupled negative-positive feedback models, providing sample model equations and simulation results which show clear oscillatory dynamics. We discuss the interplay between mathematics and biology and show how one informs the other; the deep connections between the two disciplines has helped to develop our understanding of this complex gene and paint a picture of its dynamical response. Although yet more is to be elucidated, we offer the current state-of-the-art understanding of p53 response to DNA damage. View Full-Text
Keywords: p53 models; oscillatory dynamics; negative feedback; time delays; spatial models; positive feedback p53 models; oscillatory dynamics; negative feedback; time delays; spatial models; positive feedback
Show Figures

Figure 1

MDPI and ACS Style

Eliaš, J.; Macnamara, C.K. Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey. Int. J. Mol. Sci. 2021, 22, 10590. https://doi.org/10.3390/ijms221910590

AMA Style

Eliaš J, Macnamara CK. Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey. International Journal of Molecular Sciences. 2021; 22(19):10590. https://doi.org/10.3390/ijms221910590

Chicago/Turabian Style

Eliaš, Ján, and Cicely K. Macnamara. 2021. "Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey" International Journal of Molecular Sciences 22, no. 19: 10590. https://doi.org/10.3390/ijms221910590

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop