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Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated Adipocytes

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
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Academic Editor: Stefan Jovinge
Int. J. Mol. Sci. 2021, 22(19), 10548; https://doi.org/10.3390/ijms221910548
Received: 28 August 2021 / Revised: 15 September 2021 / Accepted: 27 September 2021 / Published: 29 September 2021
The response to DNA damage is the mechanism that allows the interaction between stress signals, inflammatory secretions, DNA repair, and maintenance of cell and tissue homeostasis. Adipocyte dysfunction is the cellular trigger for various disease states such as insulin resistance, diabetes, and obesity, among many others. Previously, our group demonstrated that adipogenesis per se, from mesenchymal/stromal stem cells derived from human adipose tissue (hASCs), involves an accumulation of DNA damage and a gradual loss of the repair capacity of oxidative DNA damage. Therefore, our objective was to identify whether healthy adipocytes differentiated for the first time from hASCs, when receiving inflammatory signals induced with TNFα, were able to persistently activate the DNA Damage Response and thus trigger adipocyte dysfunction. We found that TNFα at similar levels circulating in obese humans induce a sustained response to DNA damage response as part of the Senescence-Associated Secretory Phenotype. This mechanism shows the impact of inflammatory environment early affect adipocyte function, independently of aging. View Full-Text
Keywords: DNA-damage response; TNFα; human adipocytes; γH2AX; pATM; comet assay; hASCs DNA-damage response; TNFα; human adipocytes; γH2AX; pATM; comet assay; hASCs
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MDPI and ACS Style

Valverde, M.; Sánchez-Brito, A. Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated Adipocytes. Int. J. Mol. Sci. 2021, 22, 10548. https://doi.org/10.3390/ijms221910548

AMA Style

Valverde M, Sánchez-Brito A. Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated Adipocytes. International Journal of Molecular Sciences. 2021; 22(19):10548. https://doi.org/10.3390/ijms221910548

Chicago/Turabian Style

Valverde, Mahara, and Aarón Sánchez-Brito. 2021. "Sustained Activation of TNFα-Induced DNA Damage Response in Newly Differentiated Adipocytes" International Journal of Molecular Sciences 22, no. 19: 10548. https://doi.org/10.3390/ijms221910548

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