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Review

Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions

1
Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy
2
Pathology Unit, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
3
Veneto Institute of Oncology (IOV-IRCCS), 35128 Padua, Italy
4
Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35121 Padua, Italy
5
Anatomic Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DICS), University of Genova, 16132 Genova, Italy
6
Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, 16132 Genova, Italy
7
Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, 27100 Pavia, Italy
8
UO Anatomia Patologica, Ospedale G.B. Morgagni-L. Pierantoni, 47121 Forlì, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Evgeny Imyanitov
Int. J. Mol. Sci. 2021, 22(18), 9950; https://doi.org/10.3390/ijms22189950
Received: 21 July 2021 / Revised: 3 September 2021 / Accepted: 11 September 2021 / Published: 14 September 2021
(This article belongs to the Special Issue Molecular Alterations in GastroIntestinal Pre-invasive Lesions)
Gastric carcinoma (GC) represents one of the most common and most lethal malignancies worldwide. The histopathological characterization of GC precursor lesions has provided great knowledge about gastric carcinogenesis, with the consequent introduction of effective strategies of primary and secondary prevention. In recent years, a large amount of data about the molecular events in GC development is emerging, flanking the histomorphological descriptions. In this review, we describe the landscape of molecular alterations in gastric pre-invasive lesions with a glance at their potential use in the diagnostic and therapeutic decision-making process. View Full-Text
Keywords: gastric carcinoma; pre-neoplastic lesions; gastric carcinogenesis; biomarkers; pathology gastric carcinoma; pre-neoplastic lesions; gastric carcinogenesis; biomarkers; pathology
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MDPI and ACS Style

Businello, G.; Angerilli, V.; Parente, P.; Realdon, S.; Savarino, E.; Farinati, F.; Grillo, F.; Vanoli, A.; Galuppini, F.; Paccagnella, S.; Pennelli, G.; Mastracci, L.; Saragoni, L.; Fassan, M. Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions. Int. J. Mol. Sci. 2021, 22, 9950. https://doi.org/10.3390/ijms22189950

AMA Style

Businello G, Angerilli V, Parente P, Realdon S, Savarino E, Farinati F, Grillo F, Vanoli A, Galuppini F, Paccagnella S, Pennelli G, Mastracci L, Saragoni L, Fassan M. Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions. International Journal of Molecular Sciences. 2021; 22(18):9950. https://doi.org/10.3390/ijms22189950

Chicago/Turabian Style

Businello, Gianluca, Valentina Angerilli, Paola Parente, Stefano Realdon, Edoardo Savarino, Fabio Farinati, Federica Grillo, Alessandro Vanoli, Francesca Galuppini, Silvia Paccagnella, Gianmaria Pennelli, Luca Mastracci, Luca Saragoni, and Matteo Fassan. 2021. "Molecular Landscapes of Gastric Pre-Neoplastic and Pre-Invasive Lesions" International Journal of Molecular Sciences 22, no. 18: 9950. https://doi.org/10.3390/ijms22189950

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