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Article

3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors

1
N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia
2
Institute of Chemistry, Saint Petersburg State University, Universitetsky Prospect 26, 198504 Peterhof, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Vijay Kumar Thakur
Int. J. Mol. Sci. 2021, 22(18), 9919; https://doi.org/10.3390/ijms22189919
Received: 20 August 2021 / Revised: 8 September 2021 / Accepted: 10 September 2021 / Published: 14 September 2021
The development of new drugs is accelerated by rapid access to functionalized and D-labeled molecules with improved activity and pharmacokinetic profiles. Diverse synthetic procedures often involve the usage of gaseous reagents, which can be a difficult task due to the requirement of a dedicated laboratory setup. Here, we developed a special reactor for the on-demand production of gases actively utilized in organic synthesis (C2H2, H2, C2D2, D2, and CO2) that completely eliminates the need for high-pressure equipment and allows for integrating gas generation into advanced laboratory practice. The reactor was developed by computer-aided design and manufactured using a conventional 3D printer with polypropylene and nylon filled with carbon fibers as materials. The implementation of the reactor was demonstrated in representative reactions with acetylene, such as atom-economic nucleophilic addition (conversions of 19–99%) and nickel-catalyzed S-functionalization (yields 74–99%). One of the most important advantages of the reactor is the ability to generate deuterated acetylene (C2D2) and deuterium gas (D2), which was used for highly significant, atom-economic and cost-efficient deuterium labeling of S,O-vinyl derivatives (yield 68–94%). Successful examples of their use in organic synthesis are provided to synthesize building blocks of heteroatom-functionalized and D-labeled biologically active organic molecules. View Full-Text
Keywords: 3D printing; additive manufacturing; acetylene; carbon dioxide; hydrogen; organic synthesis 3D printing; additive manufacturing; acetylene; carbon dioxide; hydrogen; organic synthesis
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MDPI and ACS Style

Erokhin, K.S.; Gordeev, E.G.; Samoylenko, D.E.; Rodygin, K.S.; Ananikov, V.P. 3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors. Int. J. Mol. Sci. 2021, 22, 9919. https://doi.org/10.3390/ijms22189919

AMA Style

Erokhin KS, Gordeev EG, Samoylenko DE, Rodygin KS, Ananikov VP. 3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors. International Journal of Molecular Sciences. 2021; 22(18):9919. https://doi.org/10.3390/ijms22189919

Chicago/Turabian Style

Erokhin, Kirill S., Evgeniy G. Gordeev, Dmitriy E. Samoylenko, Konstantin S. Rodygin, and Valentine P. Ananikov 2021. "3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors" International Journal of Molecular Sciences 22, no. 18: 9919. https://doi.org/10.3390/ijms22189919

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