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Review

Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review

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CESAM-Centre for Environmental and Marine Studies, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal
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Mass Spectrometry Centre, LAQV REQUIMTE, Department of Chemistry, Santiago University Campus, University of Aveiro, 3810-193 Aveiro, Portugal
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Department of Medical Sciences, Institute of Biomedicine–iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
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Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland
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Health Research Institute (HRI), University of Limerick, V94 T9PX Limerick, Ireland
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Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
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Instituto de Investigaciones Marinas-Consejo Superior de Investigaciones Científicas (IIM-CSIC), Eduardo Cabello 6, E-36208 Vigo, Spain
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R&D Department, Allmicroalgae Natural Products SAA, Rua 25 de Abril 1974, 2445-287 Pataias, Portugal
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Author to whom correspondence should be addressed.
Academic Editor: Nobuyuki Takahashi
Int. J. Mol. Sci. 2021, 22(18), 9825; https://doi.org/10.3390/ijms22189825
Received: 9 July 2021 / Revised: 1 September 2021 / Accepted: 8 September 2021 / Published: 11 September 2021
(This article belongs to the Section Bioactives and Nutraceuticals)
Noncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and poor dietary habits. Modulation of the inflammatory status through dietary components is a very appellative approach to fight these diseases and is supported by increasing evidence of natural and dietary components with strong anti-inflammatory activities. The consumption of bioactive lipids has a positive impact on preventing chronic inflammation and consequently NCD and AAD. Thus, new sources of bioactive lipids have been sought out. Microalgae are rich sources of bioactive lipids such as omega-6 and -3 polyunsaturated fatty acids (PUFA) and polar lipids with associated anti-inflammatory activity. PUFAs are enzymatically and non-enzymatically catalyzed to oxylipins and have a significant role in anti and pro-resolving inflammatory responses. Therefore, a large and rapidly growing body of research has been conducted in vivo and in vitro, investigating the potential anti-inflammatory activities of microalgae lipids. This review sought to summarize and critically analyze recent evidence of the anti-inflammatory potential of microalgae lipids and their possible use to prevent or mitigate chronic inflammation. View Full-Text
Keywords: microalgae; lipids; glycolipids; phospholipids; inflammation; anti-inflammatory microalgae; lipids; glycolipids; phospholipids; inflammation; anti-inflammatory
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MDPI and ACS Style

Conde, T.A.; Zabetakis, I.; Tsoupras, A.; Medina, I.; Costa, M.; Silva, J.; Neves, B.; Domingues, P.; Domingues, M.R. Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review. Int. J. Mol. Sci. 2021, 22, 9825. https://doi.org/10.3390/ijms22189825

AMA Style

Conde TA, Zabetakis I, Tsoupras A, Medina I, Costa M, Silva J, Neves B, Domingues P, Domingues MR. Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review. International Journal of Molecular Sciences. 2021; 22(18):9825. https://doi.org/10.3390/ijms22189825

Chicago/Turabian Style

Conde, Tiago Alexandre, Ioannis Zabetakis, Alexandros Tsoupras, Isabel Medina, Margarida Costa, Joana Silva, Bruno Neves, Pedro Domingues, and M. Rosário Domingues. 2021. "Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review" International Journal of Molecular Sciences 22, no. 18: 9825. https://doi.org/10.3390/ijms22189825

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