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Recent Advances in Phenolic Metabolites and Skin Cancer

Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăștur 3-5, 400372 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Academic Editor: Woo-Sik Jeong
Int. J. Mol. Sci. 2021, 22(18), 9707;
Received: 11 August 2021 / Revised: 30 August 2021 / Accepted: 3 September 2021 / Published: 8 September 2021
(This article belongs to the Special Issue Antioxidant and Cellular Defense Properties of Phytochemicals)
Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effective in the chemoprevention of skin cancer is emphasized. This review focuses on melanoma because it is the deadliest form of skin cancer, with a significantly increasing incidence in the last decades. As chemopreventive agents, we present polyphenols and their antioxidant activity, anti-inflammatory effect, their ability to balance the cell cycle and to induce apoptosis and their various other effects on skin melanoma. Besides chemoprevention, studies suggest that polyphenols can have treating abilities in some conditions. The limitations of using polyphenols are also pointed out, which are related to their poor bioavailability and stability, but as the technology is well developed, it is possible to augment the efficacy of polyphenols in the case of melanoma. View Full-Text
Keywords: skin cancer; melanoma; polyphenols; chemoprevention skin cancer; melanoma; polyphenols; chemoprevention
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MDPI and ACS Style

Pop, T.D.; Diaconeasa, Z. Recent Advances in Phenolic Metabolites and Skin Cancer. Int. J. Mol. Sci. 2021, 22, 9707.

AMA Style

Pop TD, Diaconeasa Z. Recent Advances in Phenolic Metabolites and Skin Cancer. International Journal of Molecular Sciences. 2021; 22(18):9707.

Chicago/Turabian Style

Pop, Teodora D., and Zorita Diaconeasa. 2021. "Recent Advances in Phenolic Metabolites and Skin Cancer" International Journal of Molecular Sciences 22, no. 18: 9707.

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