Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?
Round 1
Reviewer 1 Report
I consider it a good review. The English is correct and legible. The work is well organized and complete. The references are appropriate and up to date.
Scientifically, it seems correct to me and in terms of references, current publications are cited, thus highlighting new aspects and making it interesting for the reader.
Author Response
We thank the referee for his/her positive report
Reviewer 2 Report
Christophe Desmet and Coll. discuss the role of eosinophils in asthma with regard to asthma phenotypes and endotypes, suggesting that eosinophils have variable impact on asthma manifestations depending on the disease phenotype or endotype, with the possibility that different severe eosinophilic asthma phenotypes may be driven by differences in eosinophil biology (i.e. regulatory vs inflammatory eosinophils).
The review is interesting and well written.
I just add the comment that eosinophils in asthma are part of a more complex inflammatory infiltrate, where lymphocytes, fibroblasts, neutrophils and mast cells play an “interactive” role.
I suggest that Authors in a revised manuscript add a comment at least on the bidirectional mast cell–eosinophil interactions.
Author Response
We thank the referee for his/her kind appreciation. We have added a short comment to the main text (see track changes) to convey the referee's suggestion
