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Article

Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells

1
Istituto per la Ricerca e l’Innovazione Biomedica, CNR, via U. La Malfa 153, 90146 Palermo, Italy
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Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Corso Tukory 129, 90134 Palermo, Italy
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Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146 Palermo, Italy
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Istituto per la Bioeconomia, CNR, via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy
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Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy
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Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Via Divisi 83, 90133 Palermo, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Sanjay K. Srivastava
Int. J. Mol. Sci. 2021, 22(17), 9368; https://doi.org/10.3390/ijms22179368
Received: 27 July 2021 / Revised: 24 August 2021 / Accepted: 26 August 2021 / Published: 29 August 2021
Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have opened up new therapeutic strategies in cancer research. In order to take full advantage of its vast therapeutic and preventive potential, detailed studies of the molecular mechanism involved in the antiproliferative and neuroprotective of this IntegroPectin are urgently needed. View Full-Text
Keywords: pectin; cell cycle; hydrodynamic cavitation; oxidative stress; mitochondria; neurological disease; neurodegeneration; anticancer; antitumor; phytochemicals pectin; cell cycle; hydrodynamic cavitation; oxidative stress; mitochondria; neurological disease; neurodegeneration; anticancer; antitumor; phytochemicals
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MDPI and ACS Style

Nuzzo, D.; Scordino, M.; Scurria, A.; Giardina, C.; Giordano, F.; Meneguzzo, F.; Mudò, G.; Pagliaro, M.; Picone, P.; Attanzio, A.; Raimondo, S.; Ciriminna, R.; Di Liberto, V. Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells. Int. J. Mol. Sci. 2021, 22, 9368. https://doi.org/10.3390/ijms22179368

AMA Style

Nuzzo D, Scordino M, Scurria A, Giardina C, Giordano F, Meneguzzo F, Mudò G, Pagliaro M, Picone P, Attanzio A, Raimondo S, Ciriminna R, Di Liberto V. Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells. International Journal of Molecular Sciences. 2021; 22(17):9368. https://doi.org/10.3390/ijms22179368

Chicago/Turabian Style

Nuzzo, Domenico, Miriana Scordino, Antonino Scurria, Costanza Giardina, Francesco Giordano, Francesco Meneguzzo, Giuseppa Mudò, Mario Pagliaro, Pasquale Picone, Alessandro Attanzio, Stefania Raimondo, Rosaria Ciriminna, and Valentina Di Liberto. 2021. "Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells" International Journal of Molecular Sciences 22, no. 17: 9368. https://doi.org/10.3390/ijms22179368

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