Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations
Abstract
:1. Introduction
2. Changes in ECM Components with Aging
2.1. Collagen
2.2. Fibronectin
2.3. Elastin
2.4. Laminin
2.5. Hyaluronic Acid
3. Influence of Age-Related Changes of ECM on Tissues
3.1. Mass Loss
3.2. Moisture Loss
3.3. Fibrosis
3.4. Tissue Dysfunctions
4. Utilization of ECM for Regeneration Strategies
4.1. Types of ECM-Based Materials for Biomedical Applications
4.2. ECM-Based Materials as Cell Delivery Carriers
4.3. 3D Bioprinting Using ECM-Based Bioinks
5. Future Perspectives and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ECM | Extracellular matrix |
3D dECM | Tree-dimensional Decellularized extracellular matrix |
GAGs | Glycosaminoglycans |
HA | Hyaluronic acid |
MMPs | Matrix metalloproteinase |
AGEs | Advanced glycation end products |
SC | Stem cell |
MSC | Mesenchymal stem cell |
ESC | Embryonic stem cell |
iPSC PRP | Induced pluripotent stem cell Platelet-rich plasma |
PCL PLA PVC PLGA | Polycaprolactone Polylactic acid Polyvinyl alcohol Poly(lactic-co-glycolic acid) |
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Jo, Y.; Hwang, S.H.; Jang, J. Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations. Int. J. Mol. Sci. 2021, 22, 9367. https://doi.org/10.3390/ijms22179367
Jo Y, Hwang SH, Jang J. Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations. International Journal of Molecular Sciences. 2021; 22(17):9367. https://doi.org/10.3390/ijms22179367
Chicago/Turabian StyleJo, Yeonggwon, Seung Hyeon Hwang, and Jinah Jang. 2021. "Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations" International Journal of Molecular Sciences 22, no. 17: 9367. https://doi.org/10.3390/ijms22179367
APA StyleJo, Y., Hwang, S. H., & Jang, J. (2021). Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations. International Journal of Molecular Sciences, 22(17), 9367. https://doi.org/10.3390/ijms22179367