Negative Influence by the Force: Mechanically Induced Hyperpolarization via K2P Background Potassium Channels
Abstract
:1. Introduction
2. Mechanical Activation of K2P Channels
2.1. A General Approach to Mechanosensitivity of K2P Ion Channels
2.2. Mechanosensitive Properties of K2P Channels as Reflected by the Currently Available Methods
2.3. The Models of TREK/TRAAK Mechanogating
3. The Physiological Roles of K2P Channel Mechanical Activation
3.1. Hyperpolarization and Relaxation of Smooth Muscle Cells in the Wall of Hollow Visceral Organs
3.1.1. Adaptive Relaxation in the Gastrointestinal Tract
3.1.2. Distension of the Urinary Bladder
3.1.3. Relaxation of the Myometrium during Pregnancy
3.2. Putative Role of the Mechanical Activation of K2P Channels in the Cardiovascular System
3.2.1. Mechanical Activation of K2P Channels in the Heart
3.2.2. Mechanical Activation of K2P Channels in the Vasculature
3.3. Mechanical Activation of K2P Channels in the Nervous System
3.3.1. Peripheral Nervous System
3.3.2. Central Nervous System
3.4. Physiological Role of the Mechanical Activation of K2P Channels in Other Locations
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lengyel, M.; Enyedi, P.; Czirják, G. Negative Influence by the Force: Mechanically Induced Hyperpolarization via K2P Background Potassium Channels. Int. J. Mol. Sci. 2021, 22, 9062. https://doi.org/10.3390/ijms22169062
Lengyel M, Enyedi P, Czirják G. Negative Influence by the Force: Mechanically Induced Hyperpolarization via K2P Background Potassium Channels. International Journal of Molecular Sciences. 2021; 22(16):9062. https://doi.org/10.3390/ijms22169062
Chicago/Turabian StyleLengyel, Miklós, Péter Enyedi, and Gábor Czirják. 2021. "Negative Influence by the Force: Mechanically Induced Hyperpolarization via K2P Background Potassium Channels" International Journal of Molecular Sciences 22, no. 16: 9062. https://doi.org/10.3390/ijms22169062