GPCR Partners as Cancer Driver Genes: Association with PH-Signal Proteins in a Distinctive Signaling Network
Abstract
:1. Introduction
1.1. PAR1&2 Associate with PH-Signal Proteins via ‘Recognition Motifs’ That Endow Junctional Accesses to Cancer Growth
1.2. Tumor Growth, In Vivo
1.3. Placenta-EVT Invasion Is Enhanced via PAR2-PH Binding Domain
1.4. PAR2 Is Dominant over PAR1
1.5. A Lead Cyclic Peptide Directed toward the PAR2 PH-Binding Domain
1.6. Identification of Candidates PH-Domain Binding Motifs in a GPCR Array
1.7. Tumor Angiogenesis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
Abbreviations
GPCRs | G-protein coupled receptors |
PARs | protease-activated receptors |
Znrf3 | zinc and ring finger 3 |
Rnf43 | ring finger protein 43 |
FZD | Frizzled |
PH | domain-pleckstrin homology domain |
FAK | focal adhesion kinase |
Gab1-Grb2 | associated binder 1 |
Sos | Son of Sevenless |
EVT | extravillous trophoblasts |
VEGF | vascular endothelial growth factor |
bFGF | basic Fibroblast Growth Factor |
mESC | mouse embryonic stem cell |
S1P1 | Sphingosine-1-phosphate receptor 1 |
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Nag, J.K.; Malka, H.; Appasamy, P.; Sedley, S.; Bar-Shavit, R. GPCR Partners as Cancer Driver Genes: Association with PH-Signal Proteins in a Distinctive Signaling Network. Int. J. Mol. Sci. 2021, 22, 8985. https://doi.org/10.3390/ijms22168985
Nag JK, Malka H, Appasamy P, Sedley S, Bar-Shavit R. GPCR Partners as Cancer Driver Genes: Association with PH-Signal Proteins in a Distinctive Signaling Network. International Journal of Molecular Sciences. 2021; 22(16):8985. https://doi.org/10.3390/ijms22168985
Chicago/Turabian StyleNag, Jeetendra Kumar, Hodaya Malka, Priyanga Appasamy, Shoshana Sedley, and Rachel Bar-Shavit. 2021. "GPCR Partners as Cancer Driver Genes: Association with PH-Signal Proteins in a Distinctive Signaling Network" International Journal of Molecular Sciences 22, no. 16: 8985. https://doi.org/10.3390/ijms22168985