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Volume 22
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10.3390/ijms22168624
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Article

Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair

by
Lena Stenberg
1,*,
Derya Burcu Hazer Rosberg
1,2,
Sho Kohyama
3,
Seigo Suganuma
4 and
Lars B. Dahlin
1,5,6
1
Department of Translational Medicine—Hand Surgery, Lund University, 205 02 Malmö, Sweden
2
Department of Neurosurgery, Faculty of Medicine, Mugla Sıtkı Kocman University, Mugla 48100, Turkey
3
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
4
Department of Orthopaedic Surgery, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, Japan
5
Department of Hand Surgery, Skåne University Hospital, 205 02 Malmö, Sweden
6
Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(16), 8624; https://doi.org/10.3390/ijms22168624
Submission received: 21 May 2021 / Revised: 3 August 2021 / Accepted: 6 August 2021 / Published: 11 August 2021
(This article belongs to the Special Issue Regenerative Medicine for Peripheral Nerve Injury: Recent Advances, Emerging Therapies and Future Directions)
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Abstract

We investigated injury-induced heat shock protein 27 (HSP27) expression and its association to axonal outgrowth after injury and different nerve repair models in healthy Wistar and diabetic Goto-Kakizaki rats. By immunohistochemistry, expression of HSP27 in sciatic nerves and DRG and axonal outgrowth (neurofilaments) in sciatic nerves were analyzed after no, immediate, and delayed (7-day delay) nerve repairs (7- or 14-day follow-up). An increased HSP27 expression in nerves and in DRG at the uninjured side was associated with diabetes. HSP27 expression in nerves and in DRG increased substantially after the nerve injuries, being higher at the site where axons and Schwann cells interacted. Regression analysis indicated a positive influence of immediate nerve repair compared to an unrepaired injury, but a shortly delayed nerve repair had no impact on axonal outgrowth. Diabetes was associated with a decreased axonal outgrowth. The increased expression of HSP27 in sciatic nerve and DRG did not influence axonal outgrowth. Injured sciatic nerves should appropriately be repaired in healthy and diabetic rats, but a short delay does not influence axonal outgrowth. HSP27 expression in sciatic nerve or DRG, despite an increase after nerve injury with or without a repair, is not associated with any alteration in axonal outgrowth.
Keywords: HSP27; diabetes; nerve injury; nerve repair; DRG HSP27; diabetes; nerve injury; nerve repair; DRG
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MDPI and ACS Style

Stenberg, L.; Hazer Rosberg, D.B.; Kohyama, S.; Suganuma, S.; Dahlin, L.B. Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair. Int. J. Mol. Sci. 2021, 22, 8624. https://doi.org/10.3390/ijms22168624

AMA Style

Stenberg L, Hazer Rosberg DB, Kohyama S, Suganuma S, Dahlin LB. Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair. International Journal of Molecular Sciences. 2021; 22(16):8624. https://doi.org/10.3390/ijms22168624

Chicago/Turabian Style

Stenberg, Lena, Derya Burcu Hazer Rosberg, Sho Kohyama, Seigo Suganuma, and Lars B. Dahlin. 2021. "Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair" International Journal of Molecular Sciences 22, no. 16: 8624. https://doi.org/10.3390/ijms22168624

APA Style

Stenberg, L., Hazer Rosberg, D. B., Kohyama, S., Suganuma, S., & Dahlin, L. B. (2021). Injury-Induced HSP27 Expression in Peripheral Nervous Tissue Is Not Associated with Any Alteration in Axonal Outgrowth after Immediate or Delayed Nerve Repair. International Journal of Molecular Sciences, 22(16), 8624. https://doi.org/10.3390/ijms22168624

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