The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Searches of Maximal Lifespan
4.2. Protein Similarity Searches
4.3. Transcriptome Assemblies
4.4. p53 Protein Tree and Real Phylogenetic Tree Construction
4.5. Prediction and Statistical Evaluation Using PROVEAN
4.6. Modeling of 3D Protein Structures
4.7. Correlation of the Maximal Lifespan and Alterations within the p53 Core Domain in Vertebrates
4.8. Convergent Evolution
4.9. Gene Gain and Losses
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Organism Classification | Maximal Lifespan (y) | Adult Weight (kg) | p53 Oddities | Effect Predicted by PROVEAN |
---|---|---|---|---|
Balaena mysticetus Mammalia, Cetacea | 211 | 100,000 | Unique substitution in proline rich region | Neutral (P77L, score = −0.993) |
Myotis brandtii, Myotis lucifugus Mammalia, Chiroptera | 41 | 0.007 | Insertion in DNA-binding domain | Deleterious (P295_H296insPKQPPGS, score = −2.526) * |
Strigops habroptila Aves, Psittaciformes | 95 | 1.75 | Substitution in core domain | Deleterious (N131H, score = −3.162) * |
Proteus anguinus Amphibia, Urodela | 102 | 0.017 | Insertion nearby dimerization region | Deleterious (L188_A189insSR, score = −3.357) * |
Turritopsis sp. Cnidaria | ∞ rejuvenation | 0.001 | No p53/63/73 protein expressed (unprecedented phenomenon in the whole animal kingdom) | Not applicable |
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Bartas, M.; Brázda, V.; Volná, A.; Červeň, J.; Pečinka, P.; Zawacka-Pankau, J.E. The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity. Int. J. Mol. Sci. 2021, 22, 8512. https://doi.org/10.3390/ijms22168512
Bartas M, Brázda V, Volná A, Červeň J, Pečinka P, Zawacka-Pankau JE. The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity. International Journal of Molecular Sciences. 2021; 22(16):8512. https://doi.org/10.3390/ijms22168512
Chicago/Turabian StyleBartas, Martin, Václav Brázda, Adriana Volná, Jiří Červeň, Petr Pečinka, and Joanna E. Zawacka-Pankau. 2021. "The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity" International Journal of Molecular Sciences 22, no. 16: 8512. https://doi.org/10.3390/ijms22168512