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Article

LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition

1
Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
2
Institute of Cardiovascular Regeneration, Goethe University, 60590 Frankfurt am Main, Germany
3
German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, 60590 Frankfurt am Main, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Béatrice Charreau
Int. J. Mol. Sci. 2021, 22(15), 8088; https://doi.org/10.3390/ijms22158088
Received: 19 April 2021 / Revised: 13 July 2021 / Accepted: 22 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Advances in Endothelial Cell Biology)
Endothelial cells can acquire a mesenchymal phenotype through a process called Endothelial-to-Mesenchymal transition (EndMT). This event is found in embryonic development, but also in pathological conditions. Blood vessels lose their ability to maintain vascular homeostasis and ultimately develop atherosclerosis, pulmonary hypertension, or fibrosis. An increase in inflammatory signals causes an upregulation of EndMT transcription factors, mesenchymal markers, and a decrease in endothelial markers. In our study, we show that the induction of EndMT results in an increase in long non-coding RNA AERRIE expression. JMJD2B, a known EndMT regulator, induces AERRIE and subsequently SULF1. Silencing of AERRIE shows a partial regulation of SULF1 but showed no effect on the endothelial and mesenchymal markers. Additionally, the overexpression of AERRIE results in no significant changes in EndMT markers, suggesting that AERRIE is marginally regulating mesenchymal markers and transcription factors. This study identifies AERRIE as a novel factor in EndMT, but its mechanism of action still needs to be elucidated. View Full-Text
Keywords: Non-coding RNA; EndMT; endothelial cells Non-coding RNA; EndMT; endothelial cells
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MDPI and ACS Style

Pham, T.P.; van Bergen, A.S.; Kremer, V.; Glaser, S.F.; Dimmeler, S.; Boon, R.A. LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition. Int. J. Mol. Sci. 2021, 22, 8088. https://doi.org/10.3390/ijms22158088

AMA Style

Pham TP, van Bergen AS, Kremer V, Glaser SF, Dimmeler S, Boon RA. LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition. International Journal of Molecular Sciences. 2021; 22(15):8088. https://doi.org/10.3390/ijms22158088

Chicago/Turabian Style

Pham, Tan Phát, Anke S. van Bergen, Veerle Kremer, Simone F. Glaser, Stefanie Dimmeler, and Reinier A. Boon. 2021. "LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition" International Journal of Molecular Sciences 22, no. 15: 8088. https://doi.org/10.3390/ijms22158088

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