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Review

Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease

by 1,2 and 3,4,*
1
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
2
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
4
Institute for Translational Research in Biomedicine, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Jaap A. Joles
Int. J. Mol. Sci. 2021, 22(15), 7808; https://doi.org/10.3390/ijms22157808
Received: 21 June 2021 / Revised: 19 July 2021 / Accepted: 20 July 2021 / Published: 21 July 2021
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), three major gasotransmitters, are involved in pleiotropic biofunctions. Research on their roles in hypertension and kidney disease has greatly expanded recently. The developing kidney can be programmed by various adverse in utero conditions by so-called renal programming, giving rise to hypertension and kidney disease in adulthood. Accordingly, early gasotransmitter-based interventions may have therapeutic potential to revoke programming processes, subsequently preventing hypertension and kidney disease of developmental origins. In this review, we describe the current knowledge of NO, CO, and H2S implicated in pregnancy, including in physiological and pathophysiological processes, highlighting their key roles in hypertension and kidney disease. We summarize current evidence of gasotransmitter-based interventions for prevention of hypertension and kidney disease in animal models. Continued study is required to assess the interplay among the gasotransmitters NO, CO, and H2S and renal programming, as well as a greater focus on further clinical translation. View Full-Text
Keywords: kidney disease; gasotransmitter; carbon monoxide; hypertension; developmental origins of health and disease (DOHaD); hydrogen sulfide; asymmetric dimethylarginine; heme oxygenase; nitric oxide kidney disease; gasotransmitter; carbon monoxide; hypertension; developmental origins of health and disease (DOHaD); hydrogen sulfide; asymmetric dimethylarginine; heme oxygenase; nitric oxide
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MDPI and ACS Style

Hsu, C.-N.; Tain, Y.-L. Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease. Int. J. Mol. Sci. 2021, 22, 7808. https://doi.org/10.3390/ijms22157808

AMA Style

Hsu C-N, Tain Y-L. Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease. International Journal of Molecular Sciences. 2021; 22(15):7808. https://doi.org/10.3390/ijms22157808

Chicago/Turabian Style

Hsu, Chien-Ning, and You-Lin Tain. 2021. "Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease" International Journal of Molecular Sciences 22, no. 15: 7808. https://doi.org/10.3390/ijms22157808

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