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Article

Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation

Department of Microbiology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Korea
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Authors to whom correspondence should be addressed.
Academic Editor: Toshio Hattori
Int. J. Mol. Sci. 2021, 22(14), 7535; https://doi.org/10.3390/ijms22147535
Received: 31 May 2021 / Revised: 5 July 2021 / Accepted: 11 July 2021 / Published: 14 July 2021
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Prostaglandin E2 (PGE2) is an important biological mediator involved in the defense against Mycobacterium tuberculosis (Mtb) infection. Currently, there are no reports on the mycobacterial components that regulate PGE2 production. Previously, we have reported that RpfE-treated dendritic cells (DCs) effectively expanded the Th1 and Th17 cell responses simultaneously; however, the mechanism underlying Th1 and Th17 cell differentiation is unclear. Here, we show that PGE2 produced by RpfE-activated DCs via the MAPK and cyclooxygenase 2 signaling pathways induces Th1 and Th17 cell responses mainly via the EP4 receptor. Furthermore, mice administered intranasally with PGE2 displayed RpfE-induced antigen-specific Th1 and Th17 responses with a significant reduction in bacterial load in the lungs. Furthermore, the addition of optimal PGE2 amount to IL-2-IL-6-IL-23p19-IL-1β was essential for promoting differentiation into Th1/Th17 cells with strong bactericidal activity. These results suggest that RpfE-matured DCs produce PGE2 that induces Th1 and Th17 cell differentiation with potent anti-mycobacterial activity. View Full-Text
Keywords: tuberculosis; dendritic cell maturation; PGE2; Th1/Th17 differentiation; naïve T cell differentiation; multifunctional T cell tuberculosis; dendritic cell maturation; PGE2; Th1/Th17 differentiation; naïve T cell differentiation; multifunctional T cell
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MDPI and ACS Style

Park, H.-S.; Choi, S.; Back, Y.-W.; Lee, K.-I.; Choi, H.-G.; Kim, H.-J. Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation. Int. J. Mol. Sci. 2021, 22, 7535. https://doi.org/10.3390/ijms22147535

AMA Style

Park H-S, Choi S, Back Y-W, Lee K-I, Choi H-G, Kim H-J. Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation. International Journal of Molecular Sciences. 2021; 22(14):7535. https://doi.org/10.3390/ijms22147535

Chicago/Turabian Style

Park, Hye-Soo, Seunga Choi, Yong-Woo Back, Kang-In Lee, Han-Gyu Choi, and Hwa-Jung Kim. 2021. "Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation" International Journal of Molecular Sciences 22, no. 14: 7535. https://doi.org/10.3390/ijms22147535

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