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Cell Sources for Cultivated Meat: Applications and Considerations throughout the Production Workflow

1
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA
2
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3
Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53706, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ricardo M. Gouveia
Int. J. Mol. Sci. 2021, 22(14), 7513; https://doi.org/10.3390/ijms22147513
Received: 8 June 2021 / Revised: 8 July 2021 / Accepted: 9 July 2021 / Published: 13 July 2021
(This article belongs to the Special Issue Current Advances in Cellular Agriculture)
Cellular agriculture is an emerging scientific discipline that leverages the existing principles behind stem cell biology, tissue engineering, and animal sciences to create agricultural products from cells in vitro. Cultivated meat, also known as clean meat or cultured meat, is a prominent subfield of cellular agriculture that possesses promising potential to alleviate the negative externalities associated with conventional meat production by producing meat in vitro instead of from slaughter. A core consideration when producing cultivated meat is cell sourcing. Specifically, developing livestock cell sources that possess the necessary proliferative capacity and differentiation potential for cultivated meat production is a key technical component that must be optimized to enable scale-up for commercial production of cultivated meat. There are several possible approaches to develop cell sources for cultivated meat production, each possessing certain advantages and disadvantages. This review will discuss the current cell sources used for cultivated meat production and remaining challenges that need to be overcome to achieve scale-up of cultivated meat for commercial production. We will also discuss cell-focused considerations in other components of the cultivated meat production workflow, namely, culture medium composition, bioreactor expansion, and biomaterial tissue scaffolding. View Full-Text
Keywords: cellular agriculture; cultivated meat; cell sourcing; stem/progenitor cells; primary cells; skeletal muscle tissue engineering cellular agriculture; cultivated meat; cell sourcing; stem/progenitor cells; primary cells; skeletal muscle tissue engineering
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MDPI and ACS Style

Reiss, J.; Robertson, S.; Suzuki, M. Cell Sources for Cultivated Meat: Applications and Considerations throughout the Production Workflow. Int. J. Mol. Sci. 2021, 22, 7513. https://doi.org/10.3390/ijms22147513

AMA Style

Reiss J, Robertson S, Suzuki M. Cell Sources for Cultivated Meat: Applications and Considerations throughout the Production Workflow. International Journal of Molecular Sciences. 2021; 22(14):7513. https://doi.org/10.3390/ijms22147513

Chicago/Turabian Style

Reiss, Jacob, Samantha Robertson, and Masatoshi Suzuki. 2021. "Cell Sources for Cultivated Meat: Applications and Considerations throughout the Production Workflow" International Journal of Molecular Sciences 22, no. 14: 7513. https://doi.org/10.3390/ijms22147513

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