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Review

Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum

1
Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile
2
Carrera de Bioquímica, Departamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera, Temuco 4811230, Chile
3
Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz—Fiocruz, Rio de Janeiro 21040-361, Brazil
4
Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro—LDCIC/FCM/UERJ, Rio de Janeiro 20550-170, Brazil
5
Department of Biology, Professur für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstrasse 5, 91058 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Micoli
Int. J. Mol. Sci. 2021, 22(14), 7499; https://doi.org/10.3390/ijms22147499
Received: 29 May 2021 / Revised: 14 June 2021 / Accepted: 15 June 2021 / Published: 13 July 2021
(This article belongs to the Special Issue Antimicrobial Resistance, Molecular Mechanisms and Fight Strategies)
Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in C. striatum. This review updates global information related to antimicrobial resistance found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination. The resistome of C. striatum comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of C. striatum is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs. View Full-Text
Keywords: Corynebacterium striatum; multidrug resistance mechanisms; insertion sequences; transposons; Tn5432; MLS phenotype; resistome; emerging pathogen; pTP10 plasmid; antibiotic resistance genes Corynebacterium striatum; multidrug resistance mechanisms; insertion sequences; transposons; Tn5432; MLS phenotype; resistome; emerging pathogen; pTP10 plasmid; antibiotic resistance genes
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MDPI and ACS Style

Leyton, B.; Ramos, J.N.; Baio, P.V.P.; Veras, J.F.C.; Souza, C.; Burkovski, A.; Mattos-Guaraldi, A.L.; Vieira, V.V.; Abanto Marin, M. Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum. Int. J. Mol. Sci. 2021, 22, 7499. https://doi.org/10.3390/ijms22147499

AMA Style

Leyton B, Ramos JN, Baio PVP, Veras JFC, Souza C, Burkovski A, Mattos-Guaraldi AL, Vieira VV, Abanto Marin M. Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum. International Journal of Molecular Sciences. 2021; 22(14):7499. https://doi.org/10.3390/ijms22147499

Chicago/Turabian Style

Leyton, Benjamin, Juliana N. Ramos, Paulo V.P. Baio, João F.C. Veras, Cassius Souza, Andreas Burkovski, Ana L. Mattos-Guaraldi, Verônica V. Vieira, and Michel Abanto Marin. 2021. "Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum" International Journal of Molecular Sciences 22, no. 14: 7499. https://doi.org/10.3390/ijms22147499

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