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Volume 22
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10.3390/ijms22137095
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Review

Nanomaterials in Skin Regeneration and Rejuvenation

by
Emanuela Bellu
1,†,
Serenella Medici
2,†,
Donatella Coradduzza
1,
Sara Cruciani
1,
Evzen Amler
3,4 and
Margherita Maioli
1,5,6,*
1
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy
2
Department of Chemistry and Pharmacy, University of Sassari, Vienna 2, 07100 Sassari, Italy
3
University Centre for Energy Efficient Buildings of Czech Technical University in Prague, Trinecka 1024, 27343 Bustehrad, Czech Republic
4
Institute of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic
5
Center for Developmental Biology and Reprogramming (CEDEBIOR), Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy
6
Interuniversity Consortium I.N.B.B., Viale delle Medaglie d’Oro, 305, 00136 Roma, Italy
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to this work.
Int. J. Mol. Sci. 2021, 22(13), 7095; https://doi.org/10.3390/ijms22137095
Submission received: 24 May 2021 / Revised: 18 June 2021 / Accepted: 28 June 2021 / Published: 30 June 2021
(This article belongs to the Section Materials Science)
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Abstract

Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.
Keywords: nanomaterials; stem cells; cellular mechanisms; skin; regenerative medicine nanomaterials; stem cells; cellular mechanisms; skin; regenerative medicine

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MDPI and ACS Style

Bellu, E.; Medici, S.; Coradduzza, D.; Cruciani, S.; Amler, E.; Maioli, M. Nanomaterials in Skin Regeneration and Rejuvenation. Int. J. Mol. Sci. 2021, 22, 7095. https://doi.org/10.3390/ijms22137095

AMA Style

Bellu E, Medici S, Coradduzza D, Cruciani S, Amler E, Maioli M. Nanomaterials in Skin Regeneration and Rejuvenation. International Journal of Molecular Sciences. 2021; 22(13):7095. https://doi.org/10.3390/ijms22137095

Chicago/Turabian Style

Bellu, Emanuela, Serenella Medici, Donatella Coradduzza, Sara Cruciani, Evzen Amler, and Margherita Maioli. 2021. "Nanomaterials in Skin Regeneration and Rejuvenation" International Journal of Molecular Sciences 22, no. 13: 7095. https://doi.org/10.3390/ijms22137095

APA Style

Bellu, E., Medici, S., Coradduzza, D., Cruciani, S., Amler, E., & Maioli, M. (2021). Nanomaterials in Skin Regeneration and Rejuvenation. International Journal of Molecular Sciences, 22(13), 7095. https://doi.org/10.3390/ijms22137095

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