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NOD-Like Receptors: Guards of Cellular Homeostasis Perturbation during Infection

by 1,* and 1,2,*
1
Institute of Immunology, Friedrich-Loeffler-Institut, 17493 Greifswald, Germany
2
Faculty of Mathematics and Natural Sciences, University of Greifswald, 17489 Greifswald, Germany
*
Authors to whom correspondence should be addressed.
Academic Editors: Thomas A. Kufer and Szilvia Benko
Int. J. Mol. Sci. 2021, 22(13), 6714; https://doi.org/10.3390/ijms22136714
Received: 14 May 2021 / Revised: 14 June 2021 / Accepted: 18 June 2021 / Published: 23 June 2021
(This article belongs to the Special Issue The Diversity of Mammalian Nod-Like Receptor Functions)
The innate immune system relies on families of pattern recognition receptors (PRRs) that detect distinct conserved molecular motifs from microbes to initiate antimicrobial responses. Activation of PRRs triggers a series of signaling cascades, leading to the release of pro-inflammatory cytokines, chemokines and antimicrobials, thereby contributing to the early host defense against microbes and regulating adaptive immunity. Additionally, PRRs can detect perturbation of cellular homeostasis caused by pathogens and fine-tune the immune responses. Among PRRs, nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) have attracted particular interest in the context of cellular stress-induced inflammation during infection. Recently, mechanistic insights into the monitoring of cellular homeostasis perturbation by NLRs have been provided. We summarize the current knowledge about the disruption of cellular homeostasis by pathogens and focus on NLRs as innate immune sensors for its detection. We highlight the mechanisms employed by various pathogens to elicit cytoskeleton disruption, organelle stress as well as protein translation block, point out exemplary NLRs that guard cellular homeostasis during infection and introduce the concept of stress-associated molecular patterns (SAMPs). We postulate that integration of information about microbial patterns, danger signals, and SAMPs enables the innate immune system with adequate plasticity and precision in elaborating responses to microbes of variable virulence. View Full-Text
Keywords: innate immunity; NOD-like receptors; pathogens; cellular homeostasis; NOD1/2; NLRP3; NLRP1 innate immunity; NOD-like receptors; pathogens; cellular homeostasis; NOD1/2; NLRP3; NLRP1
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MDPI and ACS Style

Pei, G.; Dorhoi, A. NOD-Like Receptors: Guards of Cellular Homeostasis Perturbation during Infection. Int. J. Mol. Sci. 2021, 22, 6714. https://doi.org/10.3390/ijms22136714

AMA Style

Pei G, Dorhoi A. NOD-Like Receptors: Guards of Cellular Homeostasis Perturbation during Infection. International Journal of Molecular Sciences. 2021; 22(13):6714. https://doi.org/10.3390/ijms22136714

Chicago/Turabian Style

Pei, Gang, and Anca Dorhoi. 2021. "NOD-Like Receptors: Guards of Cellular Homeostasis Perturbation during Infection" International Journal of Molecular Sciences 22, no. 13: 6714. https://doi.org/10.3390/ijms22136714

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