Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology

Herrera-Pérez, Salvador; Campos-Ríos, Ana; Rueda-Ruzafa, Lola; Lamas, José Antonio

doi:10.3390/ijms22126635

Open AccessReview

Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology

Laboratory of Neuroscience, Department of Functional Biology and Health Sciences, CINBIO, University of Vigo, 36310 Vigo, Spain

^*

Authors to whom correspondence should be addressed.

^†

Current address: Grupo de Neurofisiología Experimental y Circuitos Neuronales, Hospital Nacional de Parapléjicos, SESCAM, 45004 Toledo, Spain.

Int. J. Mol. Sci. 2021, 22(12), 6635; https://doi.org/10.3390/ijms22126635

Submission received: 17 May 2021 / Revised: 8 June 2021 / Accepted: 18 June 2021 / Published: 21 June 2021

(This article belongs to the Special Issue Membrane Channels in Health and Diseases)

Download

Browse Figure

Versions Notes

Abstract

Years before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P channels). K2P channels were later detected in cardiac tissue by RT-PCR, although the distribution of the different K2P subfamilies in the heart seems to depend on the species analyzed. In order to collect relevant information in this regard, we focus here on the TWIK, TASK and TREK cardiac channels, their putative roles in cardiac physiology and their implication in coronary pathologies. Most of the RNA expression data and electrophysiological recordings available to date support the presence of these different K2P subfamilies in distinct cardiac cells. Likewise, we show how these channels may be involved in certain pathologies, such as atrial fibrillation, long QT syndrome and Brugada syndrome.

Keywords: K2P channels; TWIK; TASK; TREK; heart

Share and Cite

MDPI and ACS Style

Herrera-Pérez, S.; Campos-Ríos, A.; Rueda-Ruzafa, L.; Lamas, J.A. Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology. Int. J. Mol. Sci. 2021, 22, 6635. https://doi.org/10.3390/ijms22126635

AMA Style

Herrera-Pérez S, Campos-Ríos A, Rueda-Ruzafa L, Lamas JA. Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology. International Journal of Molecular Sciences. 2021; 22(12):6635. https://doi.org/10.3390/ijms22126635

Chicago/Turabian Style

Herrera-Pérez, Salvador, Ana Campos-Ríos, Lola Rueda-Ruzafa, and José Antonio Lamas. 2021. "Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology" International Journal of Molecular Sciences 22, no. 12: 6635. https://doi.org/10.3390/ijms22126635

APA Style

Herrera-Pérez, S., Campos-Ríos, A., Rueda-Ruzafa, L., & Lamas, J. A. (2021). Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology. International Journal of Molecular Sciences, 22(12), 6635. https://doi.org/10.3390/ijms22126635

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI