The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
Abstract
:1. Introduction
2. The Role of Fetuin-A in NAFLD; from Hepatic Steatosis to Inflammation and Fibrosis
2.1. Studies Investigating Fetuin-A in Subjects with Radiologically Diagnosed NAFLD
2.2. Studies Investigating Fetuin-A in Histologically Diagnosed Subjects with NAFLD
3. The Relationship of Fetuin-A with NAFLD Associated CVD Risk
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Author (Reference) | Study Population | Diagnosis of NAFLD | Fetuin-A Levels in NAFLD (Compared to Controls) | Association of Fetuin-A with NAFLD |
---|---|---|---|---|
Lebensztejn et al. [38] | 45 obese children with NAFLD and 30 controls | US | Higher | None |
Reinehr et al. [39] | 36 obese children with NAFLD and 14 controls | US | Higher | None |
Ou HY et al. [40] | 255 subjects with NAFLD and 255 controls | US | Higher | None |
Huang et al. [41] | 5219 middle-aged and elderly subjects | US | NE | Positive |
Cui et al. [43] | 79 subjects with NAFLD and 79 controls | US | Lower | Positive |
Sato et al. [44] | 295 subjects with NAFLD | US | NE | Negative |
Thompson et al. [42] | 78 subjects with NAFLD | CT | NE | None |
Yilmaz et al. [45] | 99 subjects with NAFLD and 75 controls | Liver bx | Higher | Positive |
Haukeland et al. [46] | 111 subjects with NAFLD and 131 controls | Liver bx | Higher | Positive |
Ou et al. [47] | 90 subjects with NAFLD and 90 controls | Liver bx | Higher | NE |
Celebi et al. [48] | 105 subjects with NAFLD | Liver bx | NE | None |
Kahraman et al. [49] | 108 morbidly obese subjects with NAFLD and 10 controls | Liver bx | NS | Negative |
Rametta et al. [50] | 137 subjects with NAFLD and 260 controls | Liver bx | Higher | Positive |
Von Loeffelholz et al. [51] | 58 subjects with NAFLD | Liver bx | NE | Positive |
Pampanini et al. [52] | 160 subjects with NAFLD and 23 controls | US and Liver bx | Higher | None |
Author (Reference) | Study Population | Study Design | CVD Risk Assessment | Association of Fetuin-A with CVD Risk |
---|---|---|---|---|
Jensen et al. [62] | 3810 older subjects | Prospective | CVD event or CVD death | Negative |
Laughlin et al. [63] | 1688 women | Prospective | CVD event or CVD death | Negative |
Sun et al. [64] | 466 patients with IS | Prospective | IS | None |
Caglar et al. [65] | 198 nondiabetic patients with CKD | Retrospective | FMD and cIMT | Positive |
Zhao et al. [75] | 241 patients with T2D | Retrospective | Coronary angiography | Positive |
Weikert et al. [67] | 227 patients with MI and 168 patients with IS | Prospective | MI or IS | Positive |
Vörös et al. [68] | 171 patients with CVD and 81 controls | Cross-sectional | Biomarkers of ED | Positive |
Mori et al. [70] | 141 healthy subjects | Cross-sectional | Carotid arterial stiffness | Positive |
Sato et al. [44] | 295 subjects with NAFLD | Cross-sectional | cIMT | Negative |
Dogru et al. [72] | 115 subjects with NAFLD | Cross-sectional | Biomarkers of ED and cIMT | Positive |
Ballestri et al. [73] | 70 subjects with and without CVD | Cross-sectional | Coronary angiography | Negative |
Nascimbeni et al. [74] | 45 patients with CVD and 104 patients with PAD | Cross-sectional | CAD PAD | Positive |
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Dogru, T.; Kirik, A.; Gurel, H.; Rizvi, A.A.; Rizzo, M.; Sonmez, A. The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart. Int. J. Mol. Sci. 2021, 22, 6627. https://doi.org/10.3390/ijms22126627
Dogru T, Kirik A, Gurel H, Rizvi AA, Rizzo M, Sonmez A. The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart. International Journal of Molecular Sciences. 2021; 22(12):6627. https://doi.org/10.3390/ijms22126627
Chicago/Turabian StyleDogru, Teoman, Ali Kirik, Hasan Gurel, Ali A. Rizvi, Manfredi Rizzo, and Alper Sonmez. 2021. "The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart" International Journal of Molecular Sciences 22, no. 12: 6627. https://doi.org/10.3390/ijms22126627