Next Article in Journal
Molecular Inversion Probe-Based Sequencing of USH2A Exons and Splice Sites as a Cost-Effective Screening Tool in USH2 and arRP Cases
Next Article in Special Issue
Effect of Kinesin-5 Tail Domain on Motor Dynamics for Antiparallel Microtubule Sliding
Previous Article in Journal
Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury
Previous Article in Special Issue
The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast
 
 
Review

Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions

Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Anne Houdusse
Int. J. Mol. Sci. 2021, 22(12), 6420; https://doi.org/10.3390/ijms22126420
Received: 11 May 2021 / Accepted: 7 June 2021 / Published: 15 June 2021
(This article belongs to the Special Issue Cytoskeletal Dynamics and Regulation of Cell Cycle Progression)
Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin-5 motors, and the mechanisms by which these features relate to kinesin-5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin-5 motors in dividing as well as in non-dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin-5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins. View Full-Text
Keywords: kinesin-5; microtubules; mitosis; cell-cycle regulation of kinesin activity kinesin-5; microtubules; mitosis; cell-cycle regulation of kinesin activity
Show Figures

Figure 1

MDPI and ACS Style

Pandey, H.; Popov, M.; Goldstein-Levitin, A.; Gheber, L. Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions. Int. J. Mol. Sci. 2021, 22, 6420. https://doi.org/10.3390/ijms22126420

AMA Style

Pandey H, Popov M, Goldstein-Levitin A, Gheber L. Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions. International Journal of Molecular Sciences. 2021; 22(12):6420. https://doi.org/10.3390/ijms22126420

Chicago/Turabian Style

Pandey, Himanshu, Mary Popov, Alina Goldstein-Levitin, and Larisa Gheber. 2021. "Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions" International Journal of Molecular Sciences 22, no. 12: 6420. https://doi.org/10.3390/ijms22126420

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop