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Review

Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine?

1
Département de Biologie Médicale, Centre Scientifique de Monaco, 98000 Monaco, Monaco
2
Institute for Research on Cancer and Aging of Nice, Centre Antoine Lacassagne, CNRS UMR 7284 and IN-SERM U1081, Université Cote d’Azur, 06200 Nice, France
3
LIA ROPSE, Laboratoire International Associé Université Côte d’Azur—Centre Scientifique de Monaco, 98000 Monaco, Monaco
4
Nuclear Medicine Department, Grenoble-Alpes University Hospital, 38000 Grenoble, France
5
Laboratoire Radiopharmaceutiques Biocliniques, Univ. Grenoble Alpes, INSERM, CHU Grenoble Alpes, 38000 Grenoble, France
6
Centre Hospitalier Princesse Grace, Nuclear Medicine Department, 98000 Monaco, Monaco
*
Author to whom correspondence should be addressed.
Theses authors contributed equally to this work.
Academic Editor: Claudio Luchini
Int. J. Mol. Sci. 2021, 22(12), 6413; https://doi.org/10.3390/ijms22126413
Received: 30 April 2021 / Revised: 18 May 2021 / Accepted: 20 May 2021 / Published: 15 June 2021
(This article belongs to the Special Issue Pancreatic Ductal Adenocarcinoma: Precursors and Variants)
Pancreatic ductal adenocarcinoma (PDAC), accounting for 90–95% of all pancreatic tumors, is a highly devastating disease associated with poor prognosis. The lack of accurate diagnostic tests and failure of conventional therapies contribute to this pejorative issue. Over the last decade, the advent of theranostics in nuclear medicine has opened great opportunities for the diagnosis and treatment of several solid tumors. Several radiotracers dedicated to PDAC imaging or internal vectorized radiotherapy have been developed and some of them are currently under clinical consideration. The functional information provided by Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) could indeed provide an additive diagnostic value and thus help in the selection of patients for targeted therapies. Moreover, the therapeutic potential of β-- and α-emitter-radiolabeled agents could also overcome the resistance to conventional therapies. This review summarizes the current knowledge concerning the recent developments in the nuclear medicine field for the management of PDAC patients. View Full-Text
Keywords: PDAC; nuclear medicine; molecular imaging; internal vectorized radiotherapy PDAC; nuclear medicine; molecular imaging; internal vectorized radiotherapy
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MDPI and ACS Style

Montemagno, C.; Cassim, S.; De Leiris, N.; Durivault, J.; Faraggi, M.; Pagès, G. Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine? Int. J. Mol. Sci. 2021, 22, 6413. https://doi.org/10.3390/ijms22126413

AMA Style

Montemagno C, Cassim S, De Leiris N, Durivault J, Faraggi M, Pagès G. Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine? International Journal of Molecular Sciences. 2021; 22(12):6413. https://doi.org/10.3390/ijms22126413

Chicago/Turabian Style

Montemagno, Christopher, Shamir Cassim, Nicolas De Leiris, Jérôme Durivault, Marc Faraggi, and Gilles Pagès. 2021. "Pancreatic Ductal Adenocarcinoma: The Dawn of the Era of Nuclear Medicine?" International Journal of Molecular Sciences 22, no. 12: 6413. https://doi.org/10.3390/ijms22126413

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