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Article

Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34

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Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
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Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
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Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
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Department of Pharmacology, Faculty of Medicine, University of Thessaly, 41500 Larissa, Greece
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Laboratory of Microscopic Imaging and Specialized Biological Techniques, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland
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Department of Physiology and Pharmacology, Laboratory Affiliated to Istituto Pasteur Italia, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
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IRCCS Neuromed, Via Atinense 18, 86077 Pozzilli, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Vijay Kumar Thakur
Int. J. Mol. Sci. 2021, 22(12), 6271; https://doi.org/10.3390/ijms22126271
Received: 13 May 2021 / Revised: 2 June 2021 / Accepted: 7 June 2021 / Published: 10 June 2021
(This article belongs to the Section Materials Science)
Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells. View Full-Text
Keywords: chimeric liposomes; functional; pH-responsive; TRAM-34; drug delivery; glioblastoma chimeric liposomes; functional; pH-responsive; TRAM-34; drug delivery; glioblastoma
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MDPI and ACS Style

Naziris, N.; Pippa, N.; Sereti, E.; Chrysostomou, V.; Kędzierska, M.; Kajdanek, J.; Ionov, M.; Miłowska, K.; Balcerzak, Ł.; Garofalo, S.; Limatola, C.; Pispas, S.; Dimas, K.; Bryszewska, M.; Demetzos, C. Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34. Int. J. Mol. Sci. 2021, 22, 6271. https://doi.org/10.3390/ijms22126271

AMA Style

Naziris N, Pippa N, Sereti E, Chrysostomou V, Kędzierska M, Kajdanek J, Ionov M, Miłowska K, Balcerzak Ł, Garofalo S, Limatola C, Pispas S, Dimas K, Bryszewska M, Demetzos C. Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34. International Journal of Molecular Sciences. 2021; 22(12):6271. https://doi.org/10.3390/ijms22126271

Chicago/Turabian Style

Naziris, Nikolaos, Natassa Pippa, Evangelia Sereti, Varvara Chrysostomou, Marta Kędzierska, Jakub Kajdanek, Maksim Ionov, Katarzyna Miłowska, Łucja Balcerzak, Stefano Garofalo, Cristina Limatola, Stergios Pispas, Konstantinos Dimas, Maria Bryszewska, and Costas Demetzos. 2021. "Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34" International Journal of Molecular Sciences 22, no. 12: 6271. https://doi.org/10.3390/ijms22126271

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