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Article

Effects of Aqueous Dispersions of C60, C70 and [email protected]82 Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways

1
Laboratory of Molecular Biology, Research Centre for Medical Genetics, 1 Moskvorechye St, 115522 Moscow, Russia
2
Department of Chemistry, Lomonosov Moscow State University, 1-3 Leninskie Gory, 119991 Moscow, Russia
3
Department of Normal Physiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 11-5 Mokhovaya St, 125007 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Giulia Lionetto
Int. J. Mol. Sci. 2021, 22(11), 6130; https://doi.org/10.3390/ijms22116130
Received: 2 May 2021 / Revised: 3 June 2021 / Accepted: 5 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue Oxidative Stress and Genotoxicity: New Insights)
Background: Fullerenes and metallofullerenes can be considered promising nanopharmaceuticals themselves and as a basis for chemical modification. As reactive oxygen species homeostasis plays a vital role in cells, the study of their effect on genes involved in oxidative stress and anti-inflammatory responses are of particular importance. Methods: Human fetal lung fibroblasts were incubated with aqueous dispersions of C60, C70, and [email protected]82 in concentrations of 5 nM and 1.5 µM for 1, 3, 24, and 72 h. Cell viability, intracellular ROS, NOX4, NFκB, PRAR-γ, NRF2, heme oxygenase 1, and NAD(P)H quinone dehydrogenase 1 expression have been studied. Results & conclusion: The aqueous dispersions of C60, C70, and [email protected]82 fullerenes are active participants in reactive oxygen species (ROS) homeostasis. Low and high concentrations of aqueous fullerene dispersions (AFD) have similar effects. C70 was the most inert substance, C60 was the most active substance. All AFDs have both “prooxidant” and “antioxidant” effects but with a different balance. [email protected]82 was a substance with more pronounced antioxidant and anti-inflammatory properties, while C70 had more pronounced “prooxidant” properties. View Full-Text
Keywords: aqueous fullerene dispersions; pristine fullerenes; metallofullerenes; ROS homeostasis; oxidative stress; NOX4; Nrf2; PRAR-γ; heme oxygenase 1; NAD(P)H quinone dehydrogenase 1; anti-inflammatory pathways aqueous fullerene dispersions; pristine fullerenes; metallofullerenes; ROS homeostasis; oxidative stress; NOX4; Nrf2; PRAR-γ; heme oxygenase 1; NAD(P)H quinone dehydrogenase 1; anti-inflammatory pathways
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MDPI and ACS Style

Proskurnina, E.V.; Mikheev, I.V.; Savinova, E.A.; Ershova, E.S.; Veiko, N.N.; Kameneva, L.V.; Dolgikh, O.A.; Rodionov, I.V.; Proskurnin, M.A.; Kostyuk, S.V. Effects of Aqueous Dispersions of C60, C70 and [email protected]82 Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways. Int. J. Mol. Sci. 2021, 22, 6130. https://doi.org/10.3390/ijms22116130

AMA Style

Proskurnina EV, Mikheev IV, Savinova EA, Ershova ES, Veiko NN, Kameneva LV, Dolgikh OA, Rodionov IV, Proskurnin MA, Kostyuk SV. Effects of Aqueous Dispersions of C60, C70 and [email protected]82 Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways. International Journal of Molecular Sciences. 2021; 22(11):6130. https://doi.org/10.3390/ijms22116130

Chicago/Turabian Style

Proskurnina, Elena V., Ivan V. Mikheev, Ekaterina A. Savinova, Elizaveta S. Ershova, Natalia N. Veiko, Larisa V. Kameneva, Olga A. Dolgikh, Ivan V. Rodionov, Mikhail A. Proskurnin, and Svetlana V. Kostyuk 2021. "Effects of Aqueous Dispersions of C60, C70 and [email protected]82 Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways" International Journal of Molecular Sciences 22, no. 11: 6130. https://doi.org/10.3390/ijms22116130

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