Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development
Abstract
:1. Introduction
2. Suppression of miR-124 Functions in Cancer Cells
3. Tumor Suppressive Effects by miR-124 in Glial Lineage Cancers
4. Tumor Suppressive Effects of miR-124 in Major Cancers
5. Target Genes Responsible for the Tumor Suppressor Effect of miR-124, STAT3, and EZH2
6. Comparison with Neuronal Development, the Original Function of miR-124
7. Discussion
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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TARGET GENES | EFFECTS | REF. |
---|---|---|
AURKA | Inhibition of cell proliferation and potentiation of the temozolomide TMZ-based chemosensitivity. | [45] |
CAPNS1 | Inhibition of cell migration and invasion. | [42] |
CDK4 | Conferring radio-sensitivity. | [51] |
CDK4, CDK6, and PPP1R13L | Inhibition of cell migration, decrease in cell viability, and cell cycle arrest at the G0/G1 phase. | [47] |
CDK6 | Induce G1 cell cycle arrest. | [15] |
CDK6 | Decrease in cell proliferation and migration and conferring chemosensitivity to TMZ. | [48] |
CDK6 | Inhibition of cell proliferation. | [38] |
TEAD1, MAPK14, and SERP1 | Increase in cell death. | [41] |
EZH2 | Expression of miR-124/128/137 of artificial miRNA clusters, reduction of cell proliferation both in vitro and in vivo, and prolongation of survival in a mouse model. | [50] |
KITLG, NRP2, SEMA6D, and THBS1 | Regulation of self-renewal, apoptosis, and invasion. | [44] |
NRP1 | Arresting of cell cycle, inhibition of cell proliferation and migration, inhibition of tumor angiogenesis, and induction of apoptosis. | [49] |
PIM1 | Inhibition of cell proliferation, invasion, and aerobic glycolysis and promotion of apoptosis. | [43] |
PPP1R13L | Inhibition of cell proliferation, G1/S transition, and invasiveness. | [40] |
SDCBP | Decrease in malignancy of glioblastoma cells, inhibition of cell proliferation, migration, and invasion. | [46] |
SOS1 | Inhibition of cell proliferation. | [37] |
STAT3 | Reversing immunosuppression in the tumor microenvironment, enhancing T cell-mediated immune clearance, and inhibition of glioma growth. | [39] |
TARGET GENES | EFFECTS | REF. |
---|---|---|
AKT2 | Arresting of cell cycle at the G0/G1 phase and inhibition of cell growth, colony formation, and tumor growth without apoptosis.Inhibition of migratory and invasive abilities. | [66] |
BECN1, RELA, and SQSTM1 | Disruption of autophagy and reduction of cell survival. | [59] |
CD164 | Inhibition of tumor cell proliferation, colony formation, migration, and induction of apoptosis. | [58] |
CDH2 | Inhibition of cell proliferation and invasion. | [68] |
EZH2 | Inhibition of tumor cell proliferation and inhibition of the EMT process. | [67] |
LHX2 | Attenuation of cellular migratory and invasive abilities. | [64] |
MYO10 | Inhibition of migration and metastatic ability. | [61] |
SNAI2 | Inhibition of invasion. | [56] |
STAT3 | Inhibition of cell proliferation and induction of apoptosis. | [55] |
STAT3 | Inhibition of cell growth and colony formation and induction of apoptosis. | [32] |
STAT3 | Inhibition of cell growth and colony formation and induction of apoptosis. Increasing radio sensitivity. | [63] |
STAT3 | Inhibition of invasion and metastasis capacities. Increasing sensitivity to cisplatin. | [65] |
TXNRD1 | Improving sensitization of radiation-resistant cells to radiation. | [62] |
ZEB1 | Inhibition of migration and invasion through suppressing EMT. | [57] |
TARGET GENES | EFFECTS | REF. |
---|---|---|
DDX6 and PTB1 | Induction of apoptosis. Decreasing production of lactic acid, affecting the Warburg effect. | [74] |
VANGL1, MYH9, and SOX9 | Inhibition of tumorigenicity. | [69] |
PPP1R13L | Inhibition of cell proliferation and tumor formation. | [71] |
PTB1 | Enhancement in oxidative stress and induction of apoptosis and autophagy. | [72] |
ROCK1 | Inhibition of cell proliferation, migration, and invasion. | [70] |
STAT3 | High-intensity focused ultrasound mediated inhibition of migration. | [75] |
STAT3 | Induction of apoptosis and inhibition of tumor growth. | [76] |
TARGET GENES | EFFECTS | REF. |
---|---|---|
CASC3 | Inhibition of tumor growth. | [81] |
CDK6, IQGAP1, SMYD3, and VIM | Inhibition of cell growth. | [77] |
CLIC1 | Inhibition of cell proliferation, migration and invasion. | [83] |
EZH2 and ROCK2 | Inhibition of cell motility and invasion, and suppression of intrahepatic and pulmonary metastasis. Inhibition of EMT with impaired formation of stress fibers, filopodia, and lamellipodia. | [79] |
ITGAV and SP1 | Inhibition of migration and tumor metastasis. | [82] |
PIK3CA | Cell cycle arrest at the G0/G1 phase. | [78] |
STAT3 | Inhibition of cell proliferation and induction of apoptosis. | [80] |
TARGET GENES | EFFECTS | REF. |
---|---|---|
EZH2 | Inhibition of cell proliferation and colony formation and induction of apoptosis. Increased sensitization of 5-FU. | [87] |
EZH2 and JAG1 | Inhibition of cell growth, migration, invasion, and tumor growth. | [88] |
ROCK1 | Inhibition of cell proliferation, migration, and invasion. | [86] |
SPHK1 | Inhibition of cell proliferation and tumorigenicity. | [84] |
SPHK1 | Suppression of cell proliferation and invasion. | [85] |
TARGET GENES | EFFECTS | REF. |
---|---|---|
AKT2 | Inhibition of cell proliferation, migration, and invasion. | [94] |
CBL | Inhibition of cell proliferation and invasion. | [95] |
CD151 | Inhibition of proliferation via cell cycle arrest but does not induce apoptosis. Reduction of invasive and metastatic potential. | [90] |
CDK4 | Inhibition of cell proliferation. | [93] |
FLOT1 | Inhibition of cell growth and migration. | [91] |
IL11 | Inhibition of the survival and differentiation of osteoclast progenitor cells through cancer cell-derived microRNA-124. | [96] |
CTGF, ITGB1, RHOG, and ROCK1 | Inhibition of metastasis. | [89] |
SNAI2 | Inhibition of cell colony formation and pulmonary metastasis. | [92] |
STAT3 | Inhibition of cell proliferation and invasion. | [97] |
STAT3 | Improving sensitization of doxorubicin. | [100] |
ZEB2 | Inhibition of cell growth and migration and EMT. | [98] |
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Sanuki, R.; Yamamura, T. Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development. Int. J. Mol. Sci. 2021, 22, 5919. https://doi.org/10.3390/ijms22115919
Sanuki R, Yamamura T. Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development. International Journal of Molecular Sciences. 2021; 22(11):5919. https://doi.org/10.3390/ijms22115919
Chicago/Turabian StyleSanuki, Rikako, and Tomonori Yamamura. 2021. "Tumor Suppressive Effects of miR-124 and Its Function in Neuronal Development" International Journal of Molecular Sciences 22, no. 11: 5919. https://doi.org/10.3390/ijms22115919