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Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

1
Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
2
Department of Physiology & Pharmacology, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA 95211, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Jean-François Tanti
Int. J. Mol. Sci. 2021, 22(11), 5906; https://doi.org/10.3390/ijms22115906
Received: 14 April 2021 / Revised: 30 April 2021 / Accepted: 27 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Feature Papers in Molecular Endocrinology and Metabolism)
The concerning worldwide increase of obesity and chronic metabolic diseases, such as T2D, dyslipidemia, and cardiovascular disease, motivates further investigations into preventive and alternative therapeutic approaches. Over the past decade, there has been growing evidence that the formation and activation of thermogenic adipocytes (brown and beige) may serve as therapy to treat obesity and its associated diseases owing to its capacity to increase energy expenditure and to modulate circulating lipids and glucose levels. Thus, understanding the molecular mechanism of brown and beige adipocytes formation and activation will facilitate the development of strategies to combat metabolic disorders. Here, we provide a comprehensive overview of pathways and players involved in the development of brown and beige fat, as well as the role of thermogenic adipocytes in energy homeostasis and metabolism. Furthermore, we discuss the alterations in brown and beige adipose tissue function during obesity and explore the therapeutic potential of thermogenic activation to treat metabolic syndrome. View Full-Text
Keywords: adipose tissue; development; molecular circuits; secretome; thermogenesis; metabolism; obesity; therapy adipose tissue; development; molecular circuits; secretome; thermogenesis; metabolism; obesity; therapy
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MDPI and ACS Style

Brandão, B.B.; Poojari, A.; Rabiee, A. Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential. Int. J. Mol. Sci. 2021, 22, 5906. https://doi.org/10.3390/ijms22115906

AMA Style

Brandão BB, Poojari A, Rabiee A. Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential. International Journal of Molecular Sciences. 2021; 22(11):5906. https://doi.org/10.3390/ijms22115906

Chicago/Turabian Style

Brandão, Bruna B., Ankita Poojari, and Atefeh Rabiee. 2021. "Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential" International Journal of Molecular Sciences 22, no. 11: 5906. https://doi.org/10.3390/ijms22115906

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