Next Article in Journal
Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis
Previous Article in Journal
Functional Characterization of the Obesity-Linked Variant of the β3-Adrenergic Receptor
Article

Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-co-glycolide Microcapsule Vehicle in Intratympanic Drug Delivery for Treating Acute Acoustic Trauma

1
Department of Otorhinolaryngology–Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea
2
Department of Otolaryngology–Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 35015, Korea
3
Department of Otolaryngology–Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong 30099, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Giovanni Natile
Int. J. Mol. Sci. 2021, 22(11), 5720; https://doi.org/10.3390/ijms22115720
Received: 16 May 2021 / Revised: 22 May 2021 / Accepted: 25 May 2021 / Published: 27 May 2021
(This article belongs to the Section Biochemistry)
The treatment of acute hearing loss is clinically challenging due to the low efficacy of drug delivery into the inner ear. Local intratympanic administration of dexamethasone (D) and insulin-like growth factor 1 (IGF1) has been proposed for treatment, but they do not persist in the middle ear because they are typically delivered in fluid form. We developed a dual-vehicle drug delivery system consisting of cross-linked hyaluronic acid and polylactide-co-glycolide microcapsules. The effect and biocompatibility of the dual vehicle in delivering D and IGF1 were evaluated using an animal model of acute acoustic trauma. The dual vehicle persisted 10.9 times longer (8.7 days) in the middle ear compared with the control (standard-of-care vehicle, 0.8 days). The dual vehicle was able to sustain drug release over up to 1 to 2 months when indocyanine green was loaded as the drug. One-third of the animals experienced an inflammatory adverse reaction. However, it was transient with no sequelae, which was validated by micro CT findings, endoscopic examination, and histological assessment. Hearing restoration after acoustic trauma was satisfactory in both groups, which was further supported by comparable numbers of viable hair cells. Overall, the use of a dual vehicle for intratympanic D and IGF1 delivery may maximize the effect of drug delivery to the target organ because the residence time of the vehicle is prolonged. View Full-Text
Keywords: acute acoustic trauma; drug delivery; hyaluronic acid; microcapsule; dexamethasone; hearing loss acute acoustic trauma; drug delivery; hyaluronic acid; microcapsule; dexamethasone; hearing loss
Show Figures

Graphical abstract

MDPI and ACS Style

Cho, J.-A.; Kim, B.J.; Hwang, Y.-J.; Woo, S.-W.; Noh, T.-S.; Suh, M.-W. Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-co-glycolide Microcapsule Vehicle in Intratympanic Drug Delivery for Treating Acute Acoustic Trauma. Int. J. Mol. Sci. 2021, 22, 5720. https://doi.org/10.3390/ijms22115720

AMA Style

Cho J-A, Kim BJ, Hwang Y-J, Woo S-W, Noh T-S, Suh M-W. Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-co-glycolide Microcapsule Vehicle in Intratympanic Drug Delivery for Treating Acute Acoustic Trauma. International Journal of Molecular Sciences. 2021; 22(11):5720. https://doi.org/10.3390/ijms22115720

Chicago/Turabian Style

Cho, Jung-Ah, Bong J. Kim, Yu-Jung Hwang, Shin-Wook Woo, Tae-Soo Noh, and Myung-Whan Suh. 2021. "Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-co-glycolide Microcapsule Vehicle in Intratympanic Drug Delivery for Treating Acute Acoustic Trauma" International Journal of Molecular Sciences 22, no. 11: 5720. https://doi.org/10.3390/ijms22115720

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop