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Article

Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis

1
Department of Molecular Biology, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia
2
Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Mariarosaria Santillo
Int. J. Mol. Sci. 2021, 22(10), 5400; https://doi.org/10.3390/ijms22105400
Received: 7 May 2021 / Accepted: 18 May 2021 / Published: 20 May 2021
Central and peripheral serotonin (5HT) have opposing functions in the regulation of energy homeostasis. Both increasing 5HT signaling in the brain and decreasing 5HT signaling in the periphery have been proposed as potential treatments for obesity. This study investigates the relationship between constitutionally high or low 5HT activity and systemic net energy balance. Two sublines of rats with high and low whole-body 5HT tone, obtained by selective breeding for platelet 5HT parameters, were examined for fat accumulation in different white adipose tissue (WAT) depots, glucose/insulin tolerance, blood metabolic parameters, and expression of various metabolic genes. High-5HT animals, unlike their low-5HT counterparts, developed widespread intra-abdominal obesity associated with glucose and insulin intolerance, which worsened with age. They also had elevated blood glucose and lipid parameters but showed no significant changes in circulating leptin, resistin, and adipsin levels. Surprisingly, adiponectin levels were increased in plasma but reduced in the WAT of high-5HT rats. A limited number of metabolic genes belonging to different functional classes showed differential expression in WAT of high-5HT compared to low-5HT rats. Overall, a constitutive increase in 5HT tone is associated with a positive energy balance acting through subtle dysregulation of a broad spectrum of metabolic pathways. View Full-Text
Keywords: serotonin; obesity; metabolism; genetic rat model; adipose tissue serotonin; obesity; metabolism; genetic rat model; adipose tissue
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MDPI and ACS Style

Kesić, M.; Baković, P.; Stojković, R.; Štefulj, J.; Čičin-Šain, L. Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis. Int. J. Mol. Sci. 2021, 22, 5400. https://doi.org/10.3390/ijms22105400

AMA Style

Kesić M, Baković P, Stojković R, Štefulj J, Čičin-Šain L. Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis. International Journal of Molecular Sciences. 2021; 22(10):5400. https://doi.org/10.3390/ijms22105400

Chicago/Turabian Style

Kesić, Maja, Petra Baković, Ranko Stojković, Jasminka Štefulj, and Lipa Čičin-Šain. 2021. "Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis" International Journal of Molecular Sciences 22, no. 10: 5400. https://doi.org/10.3390/ijms22105400

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