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Article

Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

by
Ulises Gómez-Pinedo
1,*,
Yolanda García-Ávila
1,
Lucía Gallego-Villarejo
1,
Jordi A. Matías-Guiu
1,
María Soledad Benito-Martín
1,
Noelia Esteban-García
1,
Inmaculada Sanclemente-Alamán
1,
Vanesa Pytel
1,
Lidia Moreno-Jiménez
1,
Francisco Sancho-Bielsa
2,
Lucía Vidorreta-Ballesteros
1,
Paloma Montero-Escribano
1 and
Jorge Matías-Guiu
1
1
Laboratory of Neurobiology, Department of Neurology, Institute of Neurosciences, San Carlos Health Research Institute, Universidad Complutense, 28040 Madrid, Spain
2
Department of Physiology, Ciudad Real School of Medicine, Universidad de Castilla-La Mancha, 13001 Ciudad Real, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(10), 5192; https://doi.org/10.3390/ijms22105192
Submission received: 25 March 2021 / Revised: 11 May 2021 / Accepted: 11 May 2021 / Published: 14 May 2021
(This article belongs to the Special Issue Molecular Research on Neurological Visual Diseases)
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Abstract

Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. Material and Methods: We included three groups—a group of patients with AQP4–IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines. Results and Conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative.
Keywords: AQP4–IgG; neurogenesis; neural stem cells; neuromyelitis optica; NMOSD; precursor cells; remyelination AQP4–IgG; neurogenesis; neural stem cells; neuromyelitis optica; NMOSD; precursor cells; remyelination

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MDPI and ACS Style

Gómez-Pinedo, U.; García-Ávila, Y.; Gallego-Villarejo, L.; Matías-Guiu, J.A.; Benito-Martín, M.S.; Esteban-García, N.; Sanclemente-Alamán, I.; Pytel, V.; Moreno-Jiménez, L.; Sancho-Bielsa, F.; et al. Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System. Int. J. Mol. Sci. 2021, 22, 5192. https://doi.org/10.3390/ijms22105192

AMA Style

Gómez-Pinedo U, García-Ávila Y, Gallego-Villarejo L, Matías-Guiu JA, Benito-Martín MS, Esteban-García N, Sanclemente-Alamán I, Pytel V, Moreno-Jiménez L, Sancho-Bielsa F, et al. Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System. International Journal of Molecular Sciences. 2021; 22(10):5192. https://doi.org/10.3390/ijms22105192

Chicago/Turabian Style

Gómez-Pinedo, Ulises, Yolanda García-Ávila, Lucía Gallego-Villarejo, Jordi A. Matías-Guiu, María Soledad Benito-Martín, Noelia Esteban-García, Inmaculada Sanclemente-Alamán, Vanesa Pytel, Lidia Moreno-Jiménez, Francisco Sancho-Bielsa, and et al. 2021. "Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System" International Journal of Molecular Sciences 22, no. 10: 5192. https://doi.org/10.3390/ijms22105192

APA Style

Gómez-Pinedo, U., García-Ávila, Y., Gallego-Villarejo, L., Matías-Guiu, J. A., Benito-Martín, M. S., Esteban-García, N., Sanclemente-Alamán, I., Pytel, V., Moreno-Jiménez, L., Sancho-Bielsa, F., Vidorreta-Ballesteros, L., Montero-Escribano, P., & Matías-Guiu, J. (2021). Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System. International Journal of Molecular Sciences, 22(10), 5192. https://doi.org/10.3390/ijms22105192

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