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Volume 21
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Article

Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis

by
Takashi Ohtsuki
1,
Omer F. Hatipoglu
1,
Keiichi Asano
2,
Junko Inagaki
3,
Keiichiro Nishida
4 and
Satoshi Hirohata
1,*
1
Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan
2
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
3
Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
4
Department of Orthopaediac Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1,Shikata-cho, Kita-ku, Okayama 700-8558, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3140; https://doi.org/10.3390/ijms21093140
Submission received: 30 March 2020 / Revised: 24 April 2020 / Accepted: 27 April 2020 / Published: 29 April 2020
(This article belongs to the Special Issue Role of Hyaluronan, Hyaluronan Receptors and Binding Partners in Health and Disease)
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Abstract

In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1β (IL-1β) stimulation in chondrocytic cells. We also observed that ERK activation and NF-κB nuclear translocation were involved in the induction of CEMIP by IL-1β. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1β-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.
Keywords: cell migration-inducing hyaluronidase 1 (CEMIP); chondrocyte; hyaluronan; mechanical strain; nuclear factor kappa B (NF-κB); osteoarthritis cell migration-inducing hyaluronidase 1 (CEMIP); chondrocyte; hyaluronan; mechanical strain; nuclear factor kappa B (NF-κB); osteoarthritis
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MDPI and ACS Style

Ohtsuki, T.; Hatipoglu, O.F.; Asano, K.; Inagaki, J.; Nishida, K.; Hirohata, S. Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. Int. J. Mol. Sci. 2020, 21, 3140. https://doi.org/10.3390/ijms21093140

AMA Style

Ohtsuki T, Hatipoglu OF, Asano K, Inagaki J, Nishida K, Hirohata S. Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. International Journal of Molecular Sciences. 2020; 21(9):3140. https://doi.org/10.3390/ijms21093140

Chicago/Turabian Style

Ohtsuki, Takashi, Omer F. Hatipoglu, Keiichi Asano, Junko Inagaki, Keiichiro Nishida, and Satoshi Hirohata. 2020. "Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis" International Journal of Molecular Sciences 21, no. 9: 3140. https://doi.org/10.3390/ijms21093140

APA Style

Ohtsuki, T., Hatipoglu, O. F., Asano, K., Inagaki, J., Nishida, K., & Hirohata, S. (2020). Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. International Journal of Molecular Sciences, 21(9), 3140. https://doi.org/10.3390/ijms21093140

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