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Article

HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6

1
Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
2
The Lieber Institute for Brain Development, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
3
Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK
4
Developmental Genetics Unit, Institute of Biology, University of Kassel, 34132 Kassel, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 3000; https://doi.org/10.3390/ijms21083000
Received: 9 March 2020 / Revised: 17 April 2020 / Accepted: 20 April 2020 / Published: 24 April 2020
(This article belongs to the Special Issue NF-κB and Disease)
NF-κB signalling is crucial for cellular responses to inflammation but is also associated with the hypoxia response. NF-κB and hypoxia inducible factor (HIF) transcription factors possess an intense molecular crosstalk. Although it is known that HIF-1α modulates NF-κB transcriptional response, very little is understood regarding how HIF-1β contributes to NF-κB signalling. Here, we demonstrate that HIF-1β is required for full NF-κB activation in cells following canonical and non-canonical stimuli. We found that HIF-1β specifically controls TRAF6 expression in human cells but also in Drosophila melanogaster. HIF-1β binds to the TRAF6 gene and controls its expression independently of HIF-1α. Furthermore, exogenous TRAF6 expression is able to rescue all of the cellular phenotypes observed in the absence of HIF-1β. These results indicate that HIF-1β is an important regulator of NF-κB with consequences for homeostasis and human disease. View Full-Text
Keywords: NF-κB TRAF6; HIF; ARNT; Drosophila; TNF NF-κB TRAF6; HIF; ARNT; Drosophila; TNF
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MDPI and ACS Style

D’Ignazio, L.; Shakir, D.; Batie, M.; Muller, H.A.; Rocha, S. HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6. Int. J. Mol. Sci. 2020, 21, 3000. https://doi.org/10.3390/ijms21083000

AMA Style

D’Ignazio L, Shakir D, Batie M, Muller HA, Rocha S. HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6. International Journal of Molecular Sciences. 2020; 21(8):3000. https://doi.org/10.3390/ijms21083000

Chicago/Turabian Style

D’Ignazio, Laura, Dilem Shakir, Michael Batie, H. A. Muller, and Sonia Rocha. 2020. "HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6" International Journal of Molecular Sciences 21, no. 8: 3000. https://doi.org/10.3390/ijms21083000

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