Next Article in Journal
COVID-19 and RAS: Unravelling an Unclear Relationship
Next Article in Special Issue
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
Previous Article in Journal
Epidemiological and Genomic Characterization of Campylobacter jejuni Isolates from a Foodborne Outbreak at Hangzhou, China
Previous Article in Special Issue
Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators

HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6

Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
The Lieber Institute for Brain Development, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK
Developmental Genetics Unit, Institute of Biology, University of Kassel, 34132 Kassel, Germany
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 3000;
Received: 9 March 2020 / Revised: 17 April 2020 / Accepted: 20 April 2020 / Published: 24 April 2020
(This article belongs to the Special Issue NF-κB and Disease)
NF-κB signalling is crucial for cellular responses to inflammation but is also associated with the hypoxia response. NF-κB and hypoxia inducible factor (HIF) transcription factors possess an intense molecular crosstalk. Although it is known that HIF-1α modulates NF-κB transcriptional response, very little is understood regarding how HIF-1β contributes to NF-κB signalling. Here, we demonstrate that HIF-1β is required for full NF-κB activation in cells following canonical and non-canonical stimuli. We found that HIF-1β specifically controls TRAF6 expression in human cells but also in Drosophila melanogaster. HIF-1β binds to the TRAF6 gene and controls its expression independently of HIF-1α. Furthermore, exogenous TRAF6 expression is able to rescue all of the cellular phenotypes observed in the absence of HIF-1β. These results indicate that HIF-1β is an important regulator of NF-κB with consequences for homeostasis and human disease. View Full-Text
Keywords: NF-κB TRAF6; HIF; ARNT; Drosophila; TNF NF-κB TRAF6; HIF; ARNT; Drosophila; TNF
Show Figures

Figure 1

MDPI and ACS Style

D’Ignazio, L.; Shakir, D.; Batie, M.; Muller, H.A.; Rocha, S. HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6. Int. J. Mol. Sci. 2020, 21, 3000.

AMA Style

D’Ignazio L, Shakir D, Batie M, Muller HA, Rocha S. HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6. International Journal of Molecular Sciences. 2020; 21(8):3000.

Chicago/Turabian Style

D’Ignazio, Laura, Dilem Shakir, Michael Batie, H. A. Muller, and Sonia Rocha. 2020. "HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6" International Journal of Molecular Sciences 21, no. 8: 3000.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop