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The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
Open AccessReview

Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

1
Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada
2
Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), 69003 Lyon, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 2091; https://doi.org/10.3390/ijms21062091
Received: 27 February 2020 / Revised: 15 March 2020 / Accepted: 16 March 2020 / Published: 18 March 2020
Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors. View Full-Text
Keywords: hepatitis C virus; viral entry; endocytosis; fusion; cell-to-cell transmission; hepatocyte hepatitis C virus; viral entry; endocytosis; fusion; cell-to-cell transmission; hepatocyte
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MDPI and ACS Style

Colpitts, C.C.; Tsai, P.-L.; Zeisel, M.B. Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process. Int. J. Mol. Sci. 2020, 21, 2091.

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