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Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment

Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, 89081 Ulm, Germany
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Int. J. Mol. Sci. 2020, 21(5), 1560; https://doi.org/10.3390/ijms21051560
Received: 29 January 2020 / Revised: 18 February 2020 / Accepted: 21 February 2020 / Published: 25 February 2020
(This article belongs to the Special Issue Molecular Processes in Chondrocyte Biology)
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These pathogenetic processes include oxidative stress, excessive expression of catabolic enzymes, release of damage-associated molecular patterns (DAMPs), and synovial inflammation. The present review focuses on the underlying pathomechanisms of PTOA and in particular the behavior and fate of the surviving chondrocytes, comprising chondrocyte metabolism, regulated cell death, and phenotypical changes comprising hypertrophy and senescence. Moreover, possible therapeutic strategies, such as chondroanabolic stimulation, anti-oxidative and anti-inflammatory treatment, as well as novel therapeutic targets are discussed. View Full-Text
Keywords: posttraumatic osteoarthritis; therapy; chondrocytes; oxidative stress; DAMP release; synovial inflammation; CSPC; cell death; catabolism; anabolism posttraumatic osteoarthritis; therapy; chondrocytes; oxidative stress; DAMP release; synovial inflammation; CSPC; cell death; catabolism; anabolism
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Riegger, J.; Brenner, R.E. Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment. Int. J. Mol. Sci. 2020, 21, 1560.

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