Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease
Abstract
:1. Introduction
2. Lung Macrophages (LMs) in Chronic Obstructive Pulmonary Disease (COPD)
3. Origins of LMs
4. Normal Functions of LMs
5. Alveolar Macrophages (AMs) vs. Interstitial Macrophages (IMs)
6. Functional Alterations in LMs of COPD
6.1. Chemotaxis
6.2. Mediator Production by LMs
6.3. Phagocytosis of LMs
7. Apoptosis in Lung
8. LMs and Apoptosis in COPD
8.1. LM Apotosis Accociated with Cigarette Smoke Exposure
8.2. LM Apoptosis Associated with Pathogen Exposure
9. LM Apoptosis vs. Senescence in COPD
10. Therapeutic Options to Improve Macrophage Function in COPD
10.1. Macrolides
10.2. Collectins
10.3. Statins
10.4. Phosphodiesterase (PDE) Inhibitors
11. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Akata, K.; van Eeden, S.F. Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease. Int. J. Mol. Sci. 2020, 21, 853. https://doi.org/10.3390/ijms21030853
Akata K, van Eeden SF. Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease. International Journal of Molecular Sciences. 2020; 21(3):853. https://doi.org/10.3390/ijms21030853
Chicago/Turabian StyleAkata, Kentaro, and Stephan F. van Eeden. 2020. "Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease" International Journal of Molecular Sciences 21, no. 3: 853. https://doi.org/10.3390/ijms21030853