Next Article in Journal
RNA-Targeting CRISPR–Cas Systems and Their Applications
Previous Article in Journal
Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila Ovaries
Previous Article in Special Issue
IL-1β Induces SOCS2 Expression in Human Dendritic Cells
Open AccessArticle

Network between Cytokines, Cortisol and Occupational Stress in Gas and Oilfield Workers

1
Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
2
Department of Occupational Medicine, Occupational Health Service, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 1118; https://doi.org/10.3390/ijms21031118
Received: 8 January 2020 / Revised: 30 January 2020 / Accepted: 6 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue The Interleukins in Health and Disease 2019)
To test whether gas and oil field work is accompanied by stress and altered immune function, the perception of workplace stress, levels of salivary cortisol, plasma levels, and mononuclear cell production of cytokines were examined in 80 healthy workers recruited among a population of operators on gas and oilfields. Specific questionnaires for determining the perception of anxiety, occupational stress, and subjective symptoms were administered. Salivary cortisol and cytokines plasma levels were evaluated by Elisa and to investigate immune function, both spontaneous and PHA- or LPS-induced expression and production of cytokines were assessed by qRT-PCR. Workers showed medium stress levels at work, with growth and increased motivation for work, and based on salivary cortisol concentrations, were divided into two groups of ≤10 ng/mL (n = 31) or >10 ng/mL (n = 49). Statistically significant higher plasma levels of IL-6, while lower TNFα, were detected in workers with cortisol >10 ng/mL. Also, BMI, DL, JD and Job strain were significantly higher in workers with cortisol >10 ng/mL. Thus, even modest variations of cortisol might have a role in the modulation of immune response and worker’s vulnerability to health imbalance.Thus, the evaluation of immune status, in addition to cortisol levels, could be useful to prevent illnesses; exacerbation of pre-existing conditions; morbidity; and consequent absences from work, with economic repercussions. View Full-Text
Keywords: cytokines; cortisol; decision latitude (DL); job stress; oil and gas field worker; psychological demands cytokines; cortisol; decision latitude (DL); job stress; oil and gas field worker; psychological demands
Show Figures

Figure 1

MDPI and ACS Style

Reale, M.; Costantini, E.; D’Angelo, C.; Coppeta, L.; Mangifesta, R.; Jagarlapoodi, S.; Di Nicola, M.; Di Giampaolo, L. Network between Cytokines, Cortisol and Occupational Stress in Gas and Oilfield Workers. Int. J. Mol. Sci. 2020, 21, 1118.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop