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Open AccessArticle

Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans

1
Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands
2
Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands
3
Departments of Haematology and Internal Medicine, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 1077; https://doi.org/10.3390/ijms21031077
Received: 8 January 2020 / Revised: 28 January 2020 / Accepted: 4 February 2020 / Published: 6 February 2020
Patients with hereditary hemochromatosis and non-transfusion-dependent hereditary anemia develop predominantly liver iron-overload. We present a unique method allowing quantification of liver iron retention in humans during first-pass of 59Fe-labeled iron through the portal system, using standard ferrokinetic techniques measuring red cell iron uptake after oral and intravenous 59Fe administration. We present data from patients with iron deficiency (ID; N = 47), hereditary hemochromatosis (HH; N = 121) and non-transfusion-dependent hereditary anemia (HA; N = 40). Mean mucosal iron uptake and mucosal iron transfer (±SD) were elevated in patients with HH (59 ± 18%, 80 ± 15% respectively), HA (65 ± 17%, 74 ± 18%) and ID (84 ± 14%, 94 ± 6%) compared to healthy controls (43 ± 19%, 64 ± 18%) (p < 0.05) resulting in increased iron retention after 14 days compared to healthy controls in all groups (p < 0.01). The fraction of retained iron utilized for red cell production was 0.37 ± 0.17 in untreated HA, 0.55 ± 0.20 in untreated HH and 0.99 ± 0.22 in ID (p < 0.01). Interestingly, compared to red blood cell iron utilization after oral iron administration, red blood cell iron utilization was higher after injection of transferrin-bound iron in HA and HH. Liver iron retention was considerably higher in HH and HA compared to ID. We hypothesize that albumin serves as a scavenger of absorbed Fe(II) for delivering albumin-bound Fe(III) to hepatocytes. View Full-Text
Keywords: hemochromatosis 1; iron 2; NTBI 3; hereditary anemia 4; iron deficiency 5 hemochromatosis 1; iron 2; NTBI 3; hereditary anemia 4; iron deficiency 5
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MDPI and ACS Style

van Vuren, A.J.; van Wijk, R.; van Beers, E.J.; Marx, J.J.M. Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans. Int. J. Mol. Sci. 2020, 21, 1077. https://doi.org/10.3390/ijms21031077

AMA Style

van Vuren AJ, van Wijk R, van Beers EJ, Marx JJM. Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans. International Journal of Molecular Sciences. 2020; 21(3):1077. https://doi.org/10.3390/ijms21031077

Chicago/Turabian Style

van Vuren, Annelies J.; van Wijk, Richard; van Beers, Eduard J.; Marx, Joannes J.M. 2020. "Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans" Int. J. Mol. Sci. 21, no. 3: 1077. https://doi.org/10.3390/ijms21031077

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