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Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration

1
Institute of Genome Biology, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany
2
Molecular Biology and Fish Genetics Unit, Faculty of Agriculture and Environmental Sciences, University of Rostock, 18059 Rostock, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(24), 9686; https://doi.org/10.3390/ijms21249686
Received: 18 November 2020 / Revised: 11 December 2020 / Accepted: 15 December 2020 / Published: 18 December 2020
(This article belongs to the Special Issue Cell Programming for Cardiovascular Disease Modeling and Therapy)
Cardiovascular diseases represent a major health concern worldwide with few therapy options for ischemic injuries due to the limited regeneration potential of affected cardiomyocytes. Innovative cell replacement approaches could facilitate efficient regenerative therapy. However, despite extensive attempts to expand primary human cells in vitro, present technological limitations and the lack of human donors have so far prevented their broad clinical use. Cell xenotransplantation might provide an ethically acceptable unlimited source for cell replacement therapies and bridge the gap between waiting recipients and available donors. Pigs are considered the most suitable candidates as a source for xenogeneic cells and tissues due to their anatomical and physiological similarities with humans. The potential of porcine cells in the field of stem cell-based therapy and regenerative medicine is under intensive investigation. This review outlines the current progress and highlights the most promising approaches in xenogeneic cell therapy with a focus on the cardiovascular system. View Full-Text
Keywords: cell transplantation; myocardial infarction; mesenchymal stem cells; graft rejection; triple knockout pigs; genome editing; iPSCs; CRISPR/Cas cell transplantation; myocardial infarction; mesenchymal stem cells; graft rejection; triple knockout pigs; genome editing; iPSCs; CRISPR/Cas
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MDPI and ACS Style

Galow, A.-M.; Goldammer, T.; Hoeflich, A. Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration. Int. J. Mol. Sci. 2020, 21, 9686. https://doi.org/10.3390/ijms21249686

AMA Style

Galow A-M, Goldammer T, Hoeflich A. Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration. International Journal of Molecular Sciences. 2020; 21(24):9686. https://doi.org/10.3390/ijms21249686

Chicago/Turabian Style

Galow, Anne-Marie; Goldammer, Tom; Hoeflich, Andreas. 2020. "Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration" Int. J. Mol. Sci. 21, no. 24: 9686. https://doi.org/10.3390/ijms21249686

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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