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Article

Mass Spectrometric Imaging of Plasma Membrane Lipid Alteration Correlated with Amperometrically Measured Activity-Dependent Plasticity in Exocytosis

by 1,†, 2,† and 1,*
1
Department of Chemistry and Molecular Biology, University of Gothenburg, Kemivägen 10, 412 96 Gothenburg, Sweden
2
Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, 412 96 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Int. J. Mol. Sci. 2020, 21(24), 9519; https://doi.org/10.3390/ijms21249519
Received: 11 November 2020 / Revised: 11 December 2020 / Accepted: 11 December 2020 / Published: 14 December 2020
(This article belongs to the Section Biochemistry)
The mechanism of synaptic plasticity and its link to memory formation are of interest, yet relatively obscure, especially the initial chemical change in the cell membrane following transmitter release. To understand the chemical mechanism of plasticity, we studied how repetitive stimuli regulate certain membrane lipid species to enhance exocytotic release using mass spectrometric imaging. We found that increasing high-curvature lipid species and decreasing low-curvature lipids in the cell membrane favor the formation of a longer-lasting exocytotic fusion pore, resulting in higher release fraction for individual exocytotic events. The lipid changes observed following repetitive stimuli are similar to those after exposure to the cognitive enhancing drug, methylphenidate, examined in a previous study, and offer an interesting point of view regarding the link between plasticity and memory and cognition. View Full-Text
Keywords: lipid alteration; mass spectrometry imaging; repetitive stimuli; exocytosis; plasticity lipid alteration; mass spectrometry imaging; repetitive stimuli; exocytosis; plasticity
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MDPI and ACS Style

Gu, C.; Philipsen, M.H.; Ewing, A.G. Mass Spectrometric Imaging of Plasma Membrane Lipid Alteration Correlated with Amperometrically Measured Activity-Dependent Plasticity in Exocytosis. Int. J. Mol. Sci. 2020, 21, 9519. https://doi.org/10.3390/ijms21249519

AMA Style

Gu C, Philipsen MH, Ewing AG. Mass Spectrometric Imaging of Plasma Membrane Lipid Alteration Correlated with Amperometrically Measured Activity-Dependent Plasticity in Exocytosis. International Journal of Molecular Sciences. 2020; 21(24):9519. https://doi.org/10.3390/ijms21249519

Chicago/Turabian Style

Gu, Chaoyi; Philipsen, Mai H.; Ewing, Andrew G. 2020. "Mass Spectrometric Imaging of Plasma Membrane Lipid Alteration Correlated with Amperometrically Measured Activity-Dependent Plasticity in Exocytosis" Int. J. Mol. Sci. 21, no. 24: 9519. https://doi.org/10.3390/ijms21249519

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