Next Article in Journal
Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia
Next Article in Special Issue
Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface
Previous Article in Journal
Bacteriophages vB_Sen-TO17 and vB_Sen-E22, Newly Isolated Viruses from Chicken Feces, Specific for Several Salmonella enterica Strains
Previous Article in Special Issue
TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease
Open AccessReview

Meibomian Gland Dysfunction: What Have Animal Models Taught Us?

College of Optometry, University of Houston, Houston, TX 77204, USA
*
Author to whom correspondence should be addressed.
Contributed equally.
Int. J. Mol. Sci. 2020, 21(22), 8822; https://doi.org/10.3390/ijms21228822
Received: 31 October 2020 / Revised: 17 November 2020 / Accepted: 19 November 2020 / Published: 21 November 2020
(This article belongs to the Special Issue Mechanisms of Dry Eye Diseases)
Studies have estimated that currently 344 million people worldwide and 16.4 million adults in the US have some form of dry eye disease (DED). It is believed that approximately 70% of DED cases are due to some form of evaporative dry eye, for which Meibomian gland dysfunction (MGD) is the major cause. Unfortunately, currently there is no effective treatment for MGD, and solely palliative care is available. Given the importance of MGD in DED, there has been a growing interest in studying Meibomian gland development, homeostasis and pathology, and, also, in developing therapies for treating and/or preventing MGD. For such, animal models have shown to be a vital tool. Much of what is known today about the Meibomian gland and MGD was learnt from these important animal models. In particular, canine and rabbit models have been essential for studying the physiopathology and progression of DED, and the mouse model, which includes different knockout strains, has enabled the identification of specific pathways potentially involved in MGD. Herein, we provide a bibliographic review on the various animal models that have been used to study Meibomian gland development, Meibomian gland homeostasis and MGD, primarily focusing on publications between 2000 and 2020. View Full-Text
Keywords: Meibomian gland; animal models; dry eye disease Meibomian gland; animal models; dry eye disease
Show Figures

Figure 1

MDPI and ACS Style

Sun, M.; Moreno, I.Y.; Dang, M.; Coulson-Thomas, V.J. Meibomian Gland Dysfunction: What Have Animal Models Taught Us? Int. J. Mol. Sci. 2020, 21, 8822.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop