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Review

Synthetic Biology Approaches in the Development of Engineered Therapeutic Microbes

1
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
2
Innovative Biomaterials Research Center, KI for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea
3
Intelligent Synthetic Biology Center, Daejeon 34141, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8744; https://doi.org/10.3390/ijms21228744
Received: 7 October 2020 / Revised: 11 November 2020 / Accepted: 17 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue Microbial Systems and Synthetic Biology)
Since the intimate relationship between microbes and human health has been uncovered, microbes have been in the spotlight as therapeutic targets for several diseases. Microbes contribute to a wide range of diseases, such as gastrointestinal disorders, diabetes and cancer. However, as host-microbiome interactions have not been fully elucidated, treatments such as probiotic administration and fecal transplantations that are used to modulate the microbial community often cause nonspecific results with serious safety concerns. As an alternative, synthetic biology can be used to rewire microbial networks such that the microbes can function as therapeutic agents. Genetic sensors can be transformed to detect biomarkers associated with disease occurrence and progression. Moreover, microbes can be reprogrammed to produce various therapeutic molecules from the host and bacterial proteins, such as cytokines, enzymes and signaling molecules, in response to a disturbed physiological state of the host. These therapeutic treatment systems are composed of several genetic parts, either identified in bacterial endogenous regulation systems or developed through synthetic design. Such genetic components are connected to form complex genetic logic circuits for sophisticated therapy. In this review, we discussed the synthetic biology strategies that can be used to construct engineered therapeutic microbes for improved microbiome-based treatment. View Full-Text
Keywords: synthetic biology; genetic engineering; therapeutic molecules synthetic biology; genetic engineering; therapeutic molecules
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MDPI and ACS Style

Kang, M.; Choe, D.; Kim, K.; Cho, B.-K.; Cho, S. Synthetic Biology Approaches in the Development of Engineered Therapeutic Microbes. Int. J. Mol. Sci. 2020, 21, 8744. https://doi.org/10.3390/ijms21228744

AMA Style

Kang M, Choe D, Kim K, Cho B-K, Cho S. Synthetic Biology Approaches in the Development of Engineered Therapeutic Microbes. International Journal of Molecular Sciences. 2020; 21(22):8744. https://doi.org/10.3390/ijms21228744

Chicago/Turabian Style

Kang, Minjeong, Donghui Choe, Kangsan Kim, Byung-Kwan Cho, and Suhyung Cho. 2020. "Synthetic Biology Approaches in the Development of Engineered Therapeutic Microbes" International Journal of Molecular Sciences 21, no. 22: 8744. https://doi.org/10.3390/ijms21228744

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