Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells
, David J. Hodson 7,8, Johannes Broichhagen 9,10, Edward W. Tate 5, Frank Reimann 11, Victoria Salem 1, Guy A. Rutter 3,12, Tricia Tan 1, Stephen R. Bloom 1, Alejandra Tomas 3,* and Ben Jones 1,*Round 1
Reviewer 1 Report
The manuscript by Fang et al. describes the effect of ligand-specific factors in mediating the fate of GLP-1R. I suggest adding some pictures to illustrate some ofthe results related to trafficking processes.
Author Response
We thank the reviewer for the suggestion to add some pictures. We have interpreted this to mean a graphical summary of the key findings related to GLP-1R trafficking. These have been added as Figure 6 in the revised manuscript.
Reviewer 2 Report
The manuscript by Fang et al. describes the effect of ligand-specific factors in mediating the fate of GLP-1R. The authors observed that GLP-1 induces GLP-1R degradation at a lower rate with respect to Exendin-4. This is a very important topic with relevant therapeutic implication as correctly the authors report in their discussion section.
The experimental approaches are outstanding and the manuscript very well written and organized.
I strongly support the publication of the manuscript in this present form
Author Response
We thank the reviewer for their positive appraisal of our manuscript.
