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Review

The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies

1
Chair and Department of Pharmacognosy, Medical University of Lublin, 1, Chodzki str., 20-093 Lublin, Poland
2
Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin, 1, Chodźki, 20-093 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Equal contribution.
Int. J. Mol. Sci. 2020, 21(21), 8307; https://doi.org/10.3390/ijms21218307
Received: 30 September 2020 / Revised: 3 November 2020 / Accepted: 4 November 2020 / Published: 5 November 2020
Gastric cancer belongs to the heterogeneous malignancies and, according to the World Health Organization, it is the fifth most commonly diagnosed cancer in men. The aim of this review is to provide an overview on the role of natural products of plant origin in the therapy of gastric cancer and to present the potentially active metabolites which can be used in the natural therapeutical strategies as the support to the conventional treatment. Many of the naturally spread secondary metabolites have been proved to exhibit chemopreventive properties when tested on the cell lines or in vivo. This manuscript aims to discuss the pharmacological significance of both the total extracts and the single isolated metabolites in the stomach cancer prevention and to focus on their mechanisms of action. A wide variety of plant-derived anticancer metabolites from different groups presented in the manuscript that include polyphenols, terpenes, alkaloids, or sulphur-containing compounds, underlines the multidirectional nature of natural products. View Full-Text
Keywords: phytotherapy; gastric cancer; phytocompounds; natural medicine phytotherapy; gastric cancer; phytocompounds; natural medicine
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MDPI and ACS Style

Nakonieczna, S.; Grabarska, A.; Kukula-Koch, W. The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies. Int. J. Mol. Sci. 2020, 21, 8307. https://doi.org/10.3390/ijms21218307

AMA Style

Nakonieczna S, Grabarska A, Kukula-Koch W. The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies. International Journal of Molecular Sciences. 2020; 21(21):8307. https://doi.org/10.3390/ijms21218307

Chicago/Turabian Style

Nakonieczna, Sylwia, Aneta Grabarska, and Wirginia Kukula-Koch. 2020. "The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies" International Journal of Molecular Sciences 21, no. 21: 8307. https://doi.org/10.3390/ijms21218307

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