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The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections

Department of Biotechnology, Institute of Biology and Biotechnology, University of Rzeszow, 35-310 Rzeszow, Poland
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8176; https://doi.org/10.3390/ijms21218176
Received: 20 September 2020 / Revised: 28 October 2020 / Accepted: 28 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue RNA Regulatory Networks at the Crossroad of Human Diseases)
Eukaryotic 5-methylcytosine RNA methyltransferases catalyze the transfer of a methyl group to the fifth carbon of a cytosine base in RNA sequences to produce 5-methylcytosine (m5C). m5C RNA methyltransferases play a crucial role in the maintenance of functionality and stability of RNA. Viruses have developed a number of strategies to suppress host innate immunity and ensure efficient transcription and translation for the replication of new virions. One such viral strategy is to use host m5C RNA methyltransferases to modify viral RNA and thus to affect antiviral host responses. Here, we summarize the latest findings concerning the roles of m5C RNA methyltransferases, namely, NOL1/NOP2/SUN domain (NSUN) proteins and DNA methyltransferase 2/tRNA methyltransferase 1 (DNMT2/TRDMT1) during viral infections. Moreover, the use of m5C RNA methyltransferase inhibitors as an antiviral therapy is discussed. View Full-Text
Keywords: 5-methylcytosine; NSUN proteins; DNMT2/TRDMT1; viruses; antiviral drugs 5-methylcytosine; NSUN proteins; DNMT2/TRDMT1; viruses; antiviral drugs
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MDPI and ACS Style

Wnuk, M.; Slipek, P.; Dziedzic, M.; Lewinska, A. The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections. Int. J. Mol. Sci. 2020, 21, 8176. https://doi.org/10.3390/ijms21218176

AMA Style

Wnuk M, Slipek P, Dziedzic M, Lewinska A. The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections. International Journal of Molecular Sciences. 2020; 21(21):8176. https://doi.org/10.3390/ijms21218176

Chicago/Turabian Style

Wnuk, Maciej, Piotr Slipek, Mateusz Dziedzic, and Anna Lewinska. 2020. "The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections" International Journal of Molecular Sciences 21, no. 21: 8176. https://doi.org/10.3390/ijms21218176

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