Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease
Abstract
1. Introduction
2. The Biochemistry of Protein Cysteine Residues: A Basic Overview
3. Low-Molecular Weight Non-Protein Thiols in Redox Regulation: Focus on Glutathione
4. Molecular Mechanisms of Protein S-Glutathionylation
4.1. Thiol–Disulfide Exchange Mechanism
4.2. Reactive Thiol Intermediates for S-Glutathionylation
4.2.1. Sulfenic Acids
4.2.2. Sulfenyl-Amides
4.2.3. Thiyl Radicals
4.2.4. S-Nitrosylated Thiols
4.2.5. Thiosulfinates
5. Enzymatic Protein S-Glutathionylation
5.1. Glutathione S-Transferase π
5.2. Other Potential Enzymes
6. Deglutathionylation
7. Structure–Function Relationship of Protein S-Glutathionylation
8. Implications of Protein S-Glutathionylation in Diseases
8.1. Aging and Neurodegeneration
8.2. Cardiovascular Disease
8.2.1. Myocardial Infarction
8.2.2. Cardiac Hypertrophy
8.3. Cancer
8.4. Liver Disease
9. Concluding Remarks
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
ROS | reactive oxygen species |
GSH | reduced glutathione |
GSSG | oxidized glutathione |
RSSR’ | disulfide |
RSOH | sulfenic acid |
RSO2H | sulfinic acid |
RSO3H | sulfonic acid |
RSNHR’ | sulfenyl-amide |
GGT | γ-glutamyl transpeptidase |
GST | glutathione S-transferase |
Grx | glutaredoxin |
References
- Sies, H.; Jones, D.P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat. Rev. Mol. Cell Biol. 2020, 21, 363–383. [Google Scholar] [CrossRef] [PubMed]
- Panday, A.; Sahoo, M.K.; Osorio, D.; Batra, S. NADPH oxidases: An overview from structure to innate immunity-associated pathologies. Cell. Mol. Immunol. 2015, 12, 5–23. [Google Scholar] [CrossRef]
- Liguori, I.; Russo, G.; Curcio, F.; Bulli, G.; Aran, L.; Della-Morte, D.; Gargiulo, G.; Testa, G.; Cacciatore, F.; Bonaduce, D.; et al. Oxidative stress, aging, and diseases. Clin. Interv. Aging 2018, 13, 757–772. [Google Scholar] [CrossRef] [PubMed]
- Finkel, T. Signal transduction by reactive oxygen species. J. Cell Biol. 2011, 194, 7–15. [Google Scholar] [CrossRef] [PubMed]
- Sies, H. Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol. 2017, 11, 613–619. [Google Scholar] [CrossRef] [PubMed]
- Moran, L.K.; Gutteridge, J.M.; Quinlan, G.J. Thiols in cellular redox signalling and control. Curr. Med. Chem. 2001, 8, 763–772. [Google Scholar] [CrossRef]
- Leonberg, A.K.; Chai, Y.C. The functional role of cysteine residues for c-Abl kinase activity. Mol. Cell. Biochem. 2007, 304, 207–212. [Google Scholar] [CrossRef]
- Paulsen, C.E.; Carroll, K.S. Cysteine-mediated redox signaling: Chemistry, biology, and tools for discovery. Chem. Rev. 2013, 113, 4633–4679. [Google Scholar] [CrossRef]
- Mannaa, A.; Hanisch, F.G. Redox Proteomes in Human Physiology and Disease Mechanisms. J. Proteome Res. 2020, 19, 1–17. [Google Scholar] [CrossRef]
- Poole, L.B. The basics of thiols and cysteines in redox biology and chemistry. Free Radic. Biol. Med. 2015, 80, 148–157. [Google Scholar] [CrossRef]
- Marino, S.M.; Gladyshev, V.N. Analysis and functional prediction of reactive cysteine residues. J. Biol. Chem. 2012, 287, 4419–4425. [Google Scholar] [CrossRef]
- Pace, N.J.; Weerapana, E. A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chem. Biol. 2014, 9, 258–265. [Google Scholar] [CrossRef] [PubMed]
- Reddie, K.G.; Carroll, K.S. Expanding the functional diversity of proteins through cysteine oxidation. Curr. Opin. Chem. Biol. 2008, 12, 746–754. [Google Scholar] [CrossRef] [PubMed]
- Go, Y.M.; Chandler, J.D.; Jones, D.P. The cysteine proteome. Free Radic. Biol. Med. 2015, 84, 227–245. [Google Scholar] [CrossRef] [PubMed]
- Requejo, R.; Hurd, T.R.; Costa, N.J.; Murphy, M.P. Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J. 2010, 277, 1465–1480. [Google Scholar] [CrossRef]
- Ferrer-Sueta, G.; Manta, B.; Botti, H.; Radi, R.; Trujillo, M.; Denicola, A. Factors affecting protein thiol reactivity and specificity in peroxide reduction. Chem. Res. Toxicol. 2011, 24, 434–450. [Google Scholar] [CrossRef] [PubMed]
- Trujillo, M.; Alvarez, B.; Radi, R. One-and two-electron oxidation of thiols: Mechanisms, kinetics and biological fates. Free Radic. Res. 2016, 50, 150–171. [Google Scholar] [CrossRef]
- Licht, S.; Gerfen, G.J.; Stubbe, J. Thiyl radicals in ribonucleotide reductases. Science 1996, 271, 477–481. [Google Scholar] [CrossRef] [PubMed]
- Lo Conte, M.; Carroll, K.S. The redox biochemistry of protein sulfenylation and sulfinylation. J. Biol. Chem. 2013, 288, 26480–26488. [Google Scholar] [CrossRef]
- Gupta, V.; Carroll, K.S. Sulfenic acid chemistry, detection and cellular lifetime. Biochim. Biophys. Acta 2014, 1840, 847–875. [Google Scholar] [CrossRef]
- Flohé, L. The impact of thiol peroxidases on redox regulation. Free Radic. Res. 2016, 50, 126–142. [Google Scholar] [CrossRef]
- Ziegler, D.M. Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation. Annu. Rev. Biochem. 1985, 54, 305–329. [Google Scholar] [CrossRef]
- Biteau, B.; Labarre, J.; Toledano, M.B. ATP-dependent reduction of cysteine-sulphinic acid by, S. cerevisiae sulphiredoxin. Nature 2003, 425, 980–984. [Google Scholar] [CrossRef]
- Leichert, L.I.; Gehrke, F.; Gudiseva, H.V.; Blackwell, T.; Ilbert, M.; Walker, A.K.; Strahler, J.R.; Andrews, P.C.; Jakob, U. Quantifying changes in the thiol redox proteome upon oxidative stress in vivo. Proc. Natl. Acad. Sci. USA 2008, 105, 8197–8202. [Google Scholar] [CrossRef] [PubMed]
- Le Moan, N.; Clement, G.; Le Maout, S.; Tacnet, F.; Toledano, M.B. The Saccharomyces cerevisiae proteome of oxidized protein thiols: Contrasted functions for the thioredoxin and glutathione pathways. J. Biol. Chem. 2006, 281, 10420–10430. [Google Scholar] [CrossRef]
- Jones, D.P. Radical-free biology of oxidative stress. Am. J. Physiol. Cell Physiol. 2008, 295, C849–C868. [Google Scholar] [CrossRef] [PubMed]
- Held, J.M.; Gibson, B.W. Regulatory control or oxidative damage? Proteomic approaches to interrogate the role of cysteine oxidation status in biological processes. Mol. Cell. Proteom. 2012, 11, R111.013037. [Google Scholar] [CrossRef] [PubMed]
- Winterbourn, C.C.; Metodiewa, D. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. Free Radic. Biol. Med. 1999, 27, 322–328. [Google Scholar] [CrossRef]
- Winterbourn, C.C.; Hampton, M.B. Thiol chemistry and specificity in redox signaling. Free Radic. Biol. Med. 2008, 45, 549–561. [Google Scholar] [CrossRef]
- Hall, A.; Parsonage, D.; Poole, L.B.; Karplus, P.A. Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization. J. Mol. Biol. 2010, 402, 194–209. [Google Scholar] [CrossRef]
- Allen, E.M.; Mieyal, J.J. Protein-thiol oxidation and cell death: Regulatory role of glutaredoxins. Antioxid. Redox Signal. 2012, 17, 1748–1763. [Google Scholar] [CrossRef] [PubMed]
- Zhang, J.; Ye, Z.W.; Singh, S.; Townsend, D.M.; Tew, K.D. An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation. Free Radic. Biol. Med. 2018, 120, 204–216. [Google Scholar] [CrossRef] [PubMed]
- Ulrich, K.; Jakob, U. The role of thiols in antioxidant systems. Free Radic. Biol. Med. 2019, 140, 14–27. [Google Scholar] [CrossRef] [PubMed]
- Van Laer, K.; Hamilton, C.J.; Messens, J. Low-molecular-weight thiols in thiol-disulfide exchange. Antioxid. Redox Signal. 2013, 18, 642–1653. [Google Scholar] [CrossRef] [PubMed]
- Gout, I. Coenzyme A: A protective thiol in bacterial antioxidant defence. Biochem. Soc. Trans. 2019, 47, 469–476. [Google Scholar] [CrossRef]
- Newton, G.L.; Rawat, M.; La Clair, J.J.; Jothivasan, V.K.; Budiarto, T.; Hamilton, C.J.; Claiborne, A.; Helmann, J.D.; Fahey, R.C. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat. Chem. Biol. 2009, 5, 625–627. [Google Scholar] [CrossRef]
- Newton, G.L.; Buchmeier, N.; Fahey, R.C. Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol. Mol. Biol. Rev. 2008, 72, 471–494. [Google Scholar] [CrossRef]
- Manta, B.; Bonilla, M.; Fiestas, L.; Sturlese, M.; Salinas, G.; Bellanda, M.; Comini, M.A. Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions. Antioxid. Redox Signal. 2018, 28, 463–486. [Google Scholar] [CrossRef]
- Lu, S.C. Glutathione synthesis. Biochim. Biophys. Acta 2013, 1830, 3143–3153. [Google Scholar] [CrossRef]
- Crawford, R.R.; Prescott, E.T.; Sylvester, C.F.; Higdon, A.N.; Shan, J.; Kilberg, M.S.; Mungrue, I.N. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element. J. Biol. Chem. 2015, 290, 15878–15891. [Google Scholar] [CrossRef]
- Kumar, A.; Tikoo, S.; Maity, S.; Sengupta, S.; Sengupta, S.; Kaur, A.; Bachhawat, A.K. Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. EMBO Rep. 2012, 13, 1095–1101. [Google Scholar] [CrossRef]
- Tsunoda, S.; Avezov, E.; Zyryanova, A.; Konno, T.; Mendes-Silva, L.; Melo, E.P.; Ron, D. Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants. Elife 2014, 3, e03421. [Google Scholar] [CrossRef]
- Forman, H.J.; Zhang, H.; Rinna, A. Glutathione: Overview of its protective roles, measurement, and biosynthesis. Mol. Asp. Med. 2009, 30, 1–12. [Google Scholar] [CrossRef]
- Hwang, C.; Sinskey, A.J.; Lodish, H.F. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 1992, 257, 1496–1502. [Google Scholar] [CrossRef]
- Pirie, N.W.; Pinhey, K.G. The Titration Curve of Glutathione. J. Biol. Chem. 1929, 84, 321–333. [Google Scholar]
- Vaish, S.; Gupta, D.; Mehrotra, R.; Mehrotra, S.; Basantani, M.K. Glutathione S-transferase: A versatile protein family. 3 Biotech. 2020, 10, 321. [Google Scholar] [CrossRef]
- Molavian, H.; Madani Tonekaboni, A.; Kohandel, M.; Sivaloganathan, S. The Synergetic Coupling among the Cellular Antioxidants Glutathione Peroxidase/Peroxiredoxin and Other Antioxidants and its Effect on the Concentration of H2O2. Sci. Rep. 2015, 5, 13620. [Google Scholar] [CrossRef]
- Matsui, R.; Ferran, B.; Oh, A.; Croteau, D.; Shao, D.; Han, J.; Pimentel, D.R.; Bachschmid, M.M. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid. Redox Signal. 2020, 32, 677–700. [Google Scholar] [CrossRef] [PubMed]
- Mieyal, J.J.; Gallogly, M.M.; Qanungo, S.; Sabens, E.A.; Shelton, M.D. Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid. Redox Signal. 2008, 10, 1941–1988. [Google Scholar] [CrossRef] [PubMed]
- Dalle-Donne, I.; Milzani, A.; Gagliano, N.; Colombo, R.; Giustarini, D.; Rossi, R. Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxid. Redox Signal. 2008, 10, 445–473. [Google Scholar] [CrossRef]
- Chai, Y.C.; Ashraf, S.S.; Rokutan, K.; Johnston, R.B., Jr.; Thomas, J.A. S-thiolation of individual human neutrophil proteins including actin by stimulation of the respiratory burst: Evidence against a role for glutathione disulfide. Arch. Biochem. Biophys. 1994, 310, 273–281. [Google Scholar] [CrossRef] [PubMed]
- Klatt, P.; Molina, E.P.; De Lacoba, M.G.; Padilla, C.A.; Martinez-Galesteo, E.; Barcena, J.A.; Lamas, S. Redox regulation of c-Jun DNA binding by reversible S-glutathiolation. FASEB J. 1999, 13, 1481–1490. [Google Scholar] [CrossRef] [PubMed]
- Zaffagnini, M.; Bedhomme, M.; Marchand, C.H.; Morisse, S.; Trost, P.; Lemaire, S.D. Redox regulation in photosynthetic organisms: Focus on glutathionylation. Antioxid. Redox Signal. 2012, 16, 567–586. [Google Scholar] [CrossRef]
- Gallogly, M.M.; Mieyal, J.J. Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress. Curr. Opin. Pharmacol. 2007, 7, 381–391. [Google Scholar] [CrossRef] [PubMed]
- Wang, J.; Sevier, C.S. Formation and Reversibility of BiP Protein Cysteine Oxidation Facilitate Cell Survival during and post Oxidative Stress. J. Biol. Chem. 2016, 291, 7541–7557. [Google Scholar] [CrossRef] [PubMed]
- Lee, S.R.; Kwon, K.S.; Kim, S.R.; Rhee, S.G. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J. Biol. Chem. 1998, 273, 15366–15372. [Google Scholar] [CrossRef]
- Denu, J.M.; Tanner, K.G. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 1998, 37, 5633–5642. [Google Scholar] [CrossRef]
- Barrett, W.C.; DeGnore, J.P.; König, S.; Fales, H.M.; Keng, Y.F.; Zhang, Z.Y.; Yim, M.B.; Chock, P.B. Regulation of PTP1B via glutathionylation of the active site cysteine 215. Biochemistry 1999, 38, 6699–6705. [Google Scholar] [CrossRef]
- Heppner, D.E.; Hristova, M.; Dustin, C.M.; Danyal, K.; Habibovic, A.; van der Vliet, A. The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling. J. Biol. Chem. 2016, 291, 23282–23293. [Google Scholar] [CrossRef]
- Zaffagnini, M.; Marchand, C.H.; Malferrari, M.; Murail, S.; Bonacchi, S.; Genovese, D.; Montalti, M.; Venturoli, G.; Falini, G.; Baaden, M.; et al. Glutathionylation primes soluble glyceraldehyde-3-phosphate dehydrogenase for late collapse into insoluble aggregates. Proc. Natl. Acad. Sci. USA 2019, 116, 26057–26065. [Google Scholar] [CrossRef]
- Salmeen, A.; Andersen, J.N.; Myers, M.P.; Meng, T.C.; Hinks, J.A.; Tonks, N.K.; Barford, D. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 2003, 423, 769–773. [Google Scholar] [CrossRef] [PubMed]
- Stoyanovsky, D.A.; Maeda, A.; Atkins, J.L.; Kagan, V.E. Assessments of thiyl radicals in biosystems: Difficulties and new applications. Anal Chem. 2011, 83, 6432–6438. [Google Scholar] [CrossRef] [PubMed]
- Frey, P.A. Radical mechanisms of enzymatic catalysis. Annu. Rev. Biochem. 2001, 70, 121–148. [Google Scholar] [CrossRef]
- Schöneich, C. Thiyl radicals and induction of protein degradation. Free Radic. Res. 2016, 50, 143–149. [Google Scholar] [CrossRef] [PubMed]
- Starke, D.W.; Chock, P.B.; Mieyal, J.J. Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction. J. Biol. Chem. 2003, 278, 14607–14613. [Google Scholar] [CrossRef] [PubMed]
- Kang, P.T.; Zhang, L.; Chen, C.L.; Chen, J.; Green, K.B.; Chen, Y.R. Protein thiyl radical mediates S-glutathionylation of complex, I. Free Radic. Biol. Med. 2012, 53, 962–973. [Google Scholar] [CrossRef] [PubMed]
- Kang, P.T.; Chen, C.L.; Chen, Y.R. Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). Free Radic. Biol. Med. 2015, 79, 56–68. [Google Scholar] [CrossRef]
- Chen, C.A.; Lin, C.H.; Druhan, L.J.; Wang, T.Y.; Chen, Y.R.; Zweier, J.L. Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling. J. Biol. Chem. 2011, 286, 29098–29107. [Google Scholar] [CrossRef]
- Zweier, J.L.; Chen, C.A.; Druhan, L.J. S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling. Antioxid. Redox Signal. 2011, 14, 1769–1775. [Google Scholar] [CrossRef]
- Foster, M.W.; Hess, D.T.; Stamler, J.S. Protein S-nitrosylation in health and disease: A current perspective. Trends Mol. Med. 2009, 15, 391–404. [Google Scholar] [CrossRef]
- Ehrenfeld, P.; Cordova, F.; Duran, W.N.; Sanchez, F.A. S-nitrosylation and its role in breast cancer angiogenesis and metastasis. Nitric Oxide 2019, 87, 52–59. [Google Scholar] [CrossRef]
- Stomberski, C.T.; Hess, D.T.; Stamler, J.S. Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling. Antioxid. Redox Signal. 2019, 30, 1331–1351. [Google Scholar] [CrossRef] [PubMed]
- Williams, D.L.H. The Chemistry of S-Nitrosothiols. Acc. Chem. Res. 1999, 32, 689–876. [Google Scholar] [CrossRef]
- Grek, C.L.; Zhang, J.; Manevich, Y.; Townsend, D.M.; Tew, K.D. Causes and consequences of cysteine S-glutathionylation. J. Biol. Chem. 2013, 288, 26497–26504. [Google Scholar] [CrossRef] [PubMed]
- Belcastro, E.; Gaucher, C.; Corti, A.; Leroy, P.; Lartaud, I.; Pompella, A. Regulation of protein function by S-nitrosation and S-glutathionylation: Processes and targets in cardiovascular pathophysiology. Biol. Chem. 2017, 398, 1267–1293. [Google Scholar] [CrossRef]
- Klatt, P.; Molina, E.P.; Lamas, S. Nitric oxide inhibits c-Jun DNA binding by specifically targeted S-glutathionylation. J. Biol. Chem. 1999, 274, 15857–15864. [Google Scholar] [CrossRef]
- Giustarini, D.; Milzani, A.; Aldini, G.; Carini, M.; Rossi, R.; Dalle-Donne, I. S-nitrosation versus S-glutathionylation of protein sulfhydryl groups by S-nitrosoglutathione. Antioxid. Redox Signal. 2005, 7, 930–939. [Google Scholar] [CrossRef]
- Mohr, S.; Hallak, H.; de Boitte, A.; Lapetina, E.G.; Brüne, B. Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase. J. Biol. Chem. 1999, 274, 9427–9430. [Google Scholar] [CrossRef]
- Dutka, T.L.; Mollica, J.P.; Lamboley, C.R.; Weerakkody, V.C.; Greening, D.W.; Posterino, G.S.; Murphy, R.M.; Lamb, G.D. S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers. Am. J. Physiol. Cell Physiol. 2017, 312, C316–C327. [Google Scholar] [CrossRef]
- Huang, K.P.; Huang, F.L. Glutathionylation of proteins by glutathione disulfide S-oxide. Biochem. Pharmacol. 2002, 64, 1049–1056. [Google Scholar] [CrossRef]
- Li, J.; Huang, F.L.; Huang, K.P. Glutathiolation of proteins by glutathione disulfide S-oxide derived from S-nitrosoglutathione. Modifications of rat brain neurogranin/RC3 and neuromodulin/GAP-43. J. Biol. Chem. 2001, 276, 3098–3105. [Google Scholar] [CrossRef] [PubMed]
- Okamoto, T.; Akaike, T.; Sawa, T.; Miyamoto, Y.; van der Vliet, A.; Maeda, H. Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. J. Biol. Chem. 2001, 276, 29596–29602. [Google Scholar] [CrossRef]
- Sadidi, M.; Geddes, T.J.; Kuhn, D.M. S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione. Antioxid. Redox Signal. 2005, 7, 863–869. [Google Scholar] [CrossRef] [PubMed]
- Boyland, E.; Chasseaud, L.F. Enzyme-catalysed conjugations of glutathione with unsaturated compounds. Biochem. J. 1967, 104, 95–102. [Google Scholar] [CrossRef] [PubMed]
- Townsend, D.M.; Manevich, Y.; He, L.; Hutchens, S.; Pazoles, C.J.; Tew, K.D. Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress. J. Biol. Chem. 2009, 284, 436–445. [Google Scholar] [CrossRef]
- Manevich, Y.; Feinstein, S.I.; Fisher, A.B. Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST. Proc. Natl. Acad. Sci. USA 2004, 101, 3780–3785. [Google Scholar] [CrossRef]
- Bartolini, D.; Torquato, P.; Piroddi, M.; Galli, F. Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy. Biochim. Biophys. Acta Gen. Subj. 2019, 1863, 130–143. [Google Scholar] [CrossRef]
- Townsend, D.M.; He, L.; Hutchens, S.; Garrett, T.E.; Pazoles, C.J.; Tew, K.D. NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance. Cancer Res. 2008, 68, 2870–2877. [Google Scholar] [CrossRef]
- Ko, K.Y.; Lee, J.H.; Jang, J.K.; Jin, Y.; Kang, H.; Kim, I.Y. S-Glutathionylation of mouse selenoprotein W prevents oxidative stress-induced cell death by blocking the formation of an intramolecular disulfide bond. Free Radic. Biol. Med. 2019, 141, 362–371. [Google Scholar] [CrossRef]
- Ye, Z.W.; Zhang, J.; Ancrum, T.; Manevich, Y.; Townsend, D.M.; Tew, K.D. Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response. Antioxid. Redox Signal. 2017, 26, 247–261. [Google Scholar] [CrossRef]
- Carvalho, A.N.; Marques, C.; Guedes, R.C.; Castro-Caldas, M.; Rodrigues, E.; van Horssen, J.; Gama, M.J. S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection. FEBS Lett. 2016, 590, 1455–1466. [Google Scholar] [CrossRef]
- Zhang, J.; Ye, Z.W.; Chen, W.; Manevich, Y.; Mehrotra, S.; Ball, L.; Janssen-Heininger, Y.; Tew, K.D.; Townsend, D.M. S-Glutathionylation of estrogen receptor α affects dendritic cell function. J. Biol. Chem. 2018, 293, 4366–4380. [Google Scholar] [CrossRef] [PubMed]
- Uemura, T.; Tsaprailis, G.; Gerner, E.W. GSTΠ stimulates caveolin-1-regulated polyamine uptake via actin remodeling. Oncotarget 2019, 10, 5713–5723. [Google Scholar] [CrossRef] [PubMed]
- Klaus, A.; Zorman, S.; Berthier, A.; Polge, C.; Ramirez, S.; Michelland, S.; Sève, M.; Vertommen, D.; Rider, M.; Lentze, N.; et al. Glutathione S-transferases interact with AMP-activated protein kinase: Evidence for S-glutathionylation and activation in vitro. PLoS ONE 2013, 8, e62497. [Google Scholar] [CrossRef]
- Tew, K.D.; Townsend, D.M. Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification. Drug Metab. Rev. 2011, 43, 179–193. [Google Scholar] [CrossRef] [PubMed]
- Fujitani, N.; Yoneda, A.; Takahashi, M.; Takasawa, A.; Aoyama, T.; Miyazaki, T. Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction. Sci. Rep. 2019, 9, 14764. [Google Scholar] [CrossRef]
- Janssen-Heininger, Y.M.; Nolin, J.D.; Hoffman, S.M.; van der Velden, J.L.; Tully, J.E.; Lahue, K.G.; Abdalla, S.T.; Chapman, D.G.; Reynaert, N.L.; van der Vliet, A.; et al. Emerging mechanisms of glutathione-dependent chemistry in biology and disease. J. Cell Biochem. 2013, 114, 1962–1968. [Google Scholar] [CrossRef]
- Ercolani, L.; Scirè, A.; Galeazzi, R.; Massaccesi, L.; Cianfruglia, L.; Amici, A.; Piva, F.; Urbanelli, L.; Emiliani, C.; Principato, G.; et al. A possible S-glutathionylation of specific proteins by glyoxalase II: An in vitro and in silico study. Cell Biochem. Funct. 2016, 34, 620–627. [Google Scholar] [CrossRef]
- Galeazzi, R.; Laudadio, E.; Falconi, E.; Massaccesi, L.; Ercolani, L.; Mobbili, G.; Minnelli, C.; Scirè, A.; Cianfruglia, L.; Armeni, T. Protein-protein interactions of human glyoxalase II: Findings of a reliable docking protocol. Org. Biomol. Chem. 2018, 16, 5167–5177. [Google Scholar] [CrossRef]
- Brings, S.; Fleming, T.; Freichel, M.; Muckenthaler, M.U.; Herzig, S.; Nawroth, P.P. Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention. Int. J. Mol. Sci. 2017, 18, 984. [Google Scholar] [CrossRef]
- Harmel, R.; Fiedler, D. Features and regulation of non-enzymatic post-translational modifications. Nat. Chem. Biol. 2018, 14, 244–252. [Google Scholar] [CrossRef] [PubMed]
- Ren, G.; Stephan, D.; Xu, Z.; Zheng, Y.; Tang, D.; Harrison, R.S.; Kurz, M.; Jarrott, R.; Shouldice, S.R.; Hiniker, A. Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue. J. Biol. Chem. 2009, 284, 10150–10159. [Google Scholar] [CrossRef] [PubMed]
- Zimmermann, J.; Oestreicher, J.; Hess, S.; Herrmann, J.M.; Deponte, M.; Morgan, B. One cysteine is enough: A monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx. Redox Biol. 2020, 36, 101598. [Google Scholar] [CrossRef]
- Chrestensen, C.A.; Starke, D.W.; Mieyal, J.J. Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis. J. Biol. Chem. 2000, 275, 26556–26565. [Google Scholar] [CrossRef] [PubMed]
- Jung, C.H.; Thomas, J.A. S-glutathiolated hepatocyte proteins and insulin disulfides as substrates for reduction by glutaredoxin, thioredoxin, protein disulfide isomerase, and glutathione. Arch. Biochem. Biophys. 1996, 335, 61–72. [Google Scholar] [CrossRef] [PubMed]
- Herrero, E.; de la Torre-Ruiz, M.A. Monothiol glutaredoxins: A common domain for multiple functions. Cell. Mol. Life Sci. 2007, 64, 1518–1530. [Google Scholar] [CrossRef] [PubMed]
- Couturier, J.; Przybyla-Toscano, J.; Roret, T.; Didierjean, C.; Rouhier, N. The roles of glutaredoxins ligating Fe-S clusters: Sensing, transfer or repair functions? Biochim. Biophys. Acta 2015, 1853, 1513–1527. [Google Scholar] [CrossRef]
- Berndt, C.; Lillig, C.H.; Holmgren, A. Thioredoxins and glutaredoxins as facilitators of protein folding. Biochim. Biophys. Acta 2008, 1783, 641–650. [Google Scholar] [CrossRef]
- Park, J.W.; Mieyal, J.J.; Rhee, S.G.; Chock, P.B. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J. Biol. Chem. 2009, 284, 23364–23374. [Google Scholar] [CrossRef]
- Findlay, V.J.; Tapiero, H.; Townsend, D.M. Sulfiredoxin: A potential therapeutic agent? Biomed. Pharmacother. 2005, 59, 374–379. [Google Scholar] [CrossRef]
- Findlay, V.J.; Townsend, D.M.; Morris, T.E.; Fraser, J.P.; He, L.; Tew, K.D. A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res. 2006, 66, 6800–6806. [Google Scholar] [CrossRef] [PubMed]
- Shao, D.; Fry, J.L.; Han, J.; Hou, X.; Pimentel, D.R.; Matsui, R.; Cohen, R.A.; Bachschmid, M.M. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. J. Biol. Chem. 2014, 289, 7293–7306. [Google Scholar] [CrossRef] [PubMed]
- Mandato, A.; Chai, Y.C. Regulation of antigen 85C activity by reversible S-glutathionylation. IUBMB Life 2018, 70, 1111–1114. [Google Scholar] [CrossRef] [PubMed]
- Gandhirajan, R.K.; Jain, M.; Walla, B.; Johnsen, M.; Bartram, M.P.; Huynh Anh, M.; Rinschen, M.M.; Benzing, T.; Schermer, B. Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ). J. Biol. Chem. 2016, 291, 11596–11607. [Google Scholar] [CrossRef]
- Nagarkoti, S.; Dubey, M.; Sadaf, S.; Awasthi, D.; Chandra, T.; Jagavelu, K.; Kumar, S.; Dikshit, M. Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival. Inflammation 2019, 42, 2286–2296. [Google Scholar] [CrossRef]
- Sánchez, G.; Pedrozo, Z.; Domenech, R.J.; Hidalgo, C.; Donoso, P. Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle. J. Mol. Cell. Cardiol. 2005, 39, 982–991. [Google Scholar] [CrossRef]
- Yang, J.; Zhang, H.; Gong, W.; Liu, Z.; Wu, H.; Hu, W.; Chen, X.; Wang, L.; Wu, S.; Chen, C.; et al. S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid. J. Biol. Chem. 2020, 295, 8302–8324. [Google Scholar] [CrossRef]
- Porter, C.M.; Truman, A.W.; Truttmann, M.C. Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code. J. Biol. Chem. 2020, 295, 10689–10708. [Google Scholar] [CrossRef]
- Zhang, J.; Ye, Z.W.; Chen, W.; Culpepper, J.; Jiang, H.; Ball, L.E.; Mehrotra, S.; Blumental-Perry, A.; Tew, K.D.; Townsend, D.M. Altered Redox Regulation and S-Glutathionylation of BiP Contribute to Bortezomib Resistance in Multiple Myeloma Free Radic. Biol. Med. 2020, 160, 755–767. [Google Scholar] [CrossRef]
- Gething, M.J. Role and regulation of the ER chaperone BiP. Semin. Cell Dev. Biol. 1999, 10, 465–472. [Google Scholar] [CrossRef]
- Pizzino, G.; Irrera, N.; Cucinotta, M.; Pallio, G.; Mannino, F.; Arcoraci, V.; Squadrito, F.; Altavilla, D.; Bitto, A. Oxidative Stress: Harms and Benefits for Human Health. Oxid. Med. Cell. Longev. 2017, 8416763. [Google Scholar] [CrossRef]
- Zhou, L.; Chan, J.C.Y.; Chupin, S.; Gueguen, N.; Desquiret-Dumas, V.; Koh, S.K.; Li, J.; Gao, Y.; Deng, L.; Verma, C.; et al. Increased Protein S-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON). Int. J. Mol. Sci. 2020, 21, 3027. [Google Scholar] [CrossRef] [PubMed]
- Jeon, D.; Park, H.J.; Kim, H.S. Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1α in human colon cancer cells. Biochem. Biophys. Res. Commun. 2018, 495, 212–216. [Google Scholar] [CrossRef] [PubMed]
- Anathy, V.; Lahue, K.G.; Chapman, D.G.; Chia, S.B.; Casey, D.T.; Aboushousha, R.; van der Velden, J.; Elko, E.; Hoffman, S.M.; McMillan, D.H.; et al. Reducing protein oxidation reverses lung fibrosis. Nat. Med. 2018, 24, 1128–1135. [Google Scholar] [CrossRef]
- Tamma, G.; Valenti, G. Evaluating the Oxidative Stress in Renal Diseases: What Is the Role for S-Glutathionylation? Antioxid. Redox Signal. 2016, 25, 147–164. [Google Scholar] [CrossRef] [PubMed]
- Maki, K.; Nagai, K.; Suzuki, M.; Inomata, T.; Yoshida, T.; Nishimura, M. Temporal changes in glutaredoxin 1 and protein s-glutathionylation in allergic airway inflammation. PLoS ONE 2015, 10, e0122986. [Google Scholar] [CrossRef] [PubMed]
- Hong, C.; Seo, H.; Kwak, M.; Jeon, J.; Jang, J.; Jeong, E.M.; Myeong, J.; Hwang, Y.J.; Ha, K.; Kang, M.J.; et al. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease. Brain 2015, 138, 3030–3047. [Google Scholar] [CrossRef] [PubMed]
- Sánchez-Gómez, F.J.; Espinosa-Díez, C.; Dubey, M.; Dikshit, M.; Lamas, S. S-glutathionylation: Relevance in diabetes and potential role as a biomarker. Biol. Chem. 2013, 394, 1263–1280. [Google Scholar] [CrossRef]
- Nonaka, K.; Kume, N.; Urata, Y.; Seto, S.; Kohno, T.; Honda, S.; Ikeda, S.; Muroya, T.; Ikeda, Y.; Ihara, Y.; et al. Serum levels of S-glutathionylated proteins as a risk-marker for arteriosclerosis obliterans. Circ. J. 2007, 71, 100–105. [Google Scholar] [CrossRef]
- Grek, C.L.; Reyes, L.; Townsend, D.M.; Tew, K.D. S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide. BBA Clin. 2014, 2, 31–39. [Google Scholar] [CrossRef] [PubMed]
- Cui, H.; Kong, Y.; Zhang, H. Oxidative stress, mitochondrial dysfunction, and aging. J. Signal Transduct. 2012, 2012, 646354. [Google Scholar] [CrossRef]
- Harman, D. Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11, 298–300. [Google Scholar] [CrossRef]
- Zhu, Y.; Carvey, P.M.; Ling, Z. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 2006, 1090, 35–44. [Google Scholar] [CrossRef] [PubMed]
- Cha, S.J.; Kim, H.; Choi, H.J.; Lee, S.; Kim, K. Protein Glutathionylation in the Pathogenesis of Neurodegenerative Diseases. Oxid. Med. Cell. Longev. 2017, 2818565. [Google Scholar] [CrossRef]
- Hodson, R. Alzheimer’s disease. Nature 2018, 559, 7715. [Google Scholar] [CrossRef]
- Huang, W.J.; Zhang, X.; Chen, W.W. Role of oxidative stress in Alzheimer’s disease. Biomed. Rep. 2016, 4, 519–522. [Google Scholar] [CrossRef] [PubMed]
- Newman, S.F.; Sultana, R.; Perluigi, M.; Coccia, R.; Cai, J.; Pierce, W.M.; Klein, J.B.; Turner, D.M.; Butterfield, D.A. An increase in S-glutathionylated proteins in the Alzheimer’s disease inferior parietal lobule, a proteomics approach. J. Neurosci. Res. 2007, 85, 1506–1514. [Google Scholar] [CrossRef]
- Di Domenico, F.; Cenini, G.; Sultana, R.; Perluigi, M.; Uberti, D.; Memo, M.; Butterfield, D.A. Glutathionylation of the pro-apoptotic protein p53 in Alzheimer’s disease brain: Implications for AD pathogenesis. Neurochem. Res. 2009, 34, 727–733. [Google Scholar] [CrossRef] [PubMed]
- Rani, P.; Krishnan, S.; Rani Cathrine, C. Study on Analysis of Peripheral Biomarkers for Alzheimer’s Disease Diagnosis. Front. Neurol. 2017, 8, 328. [Google Scholar] [CrossRef] [PubMed]
- Bonora, M.; Wieckowski, M.R.; Sinclair, D.A.; Kroemer, G.; Pinton, P.; Galluzzi, L. Targeting mitochondria for cardiovascular disorders: Therapeutic potential and obstacles. Nat. Rev. Cardiol. 2019, 16, 33–55. [Google Scholar] [CrossRef]
- Tahrir, F.G.; Langford, D.; Amini, S.; Mohseni Ahooyi, T.; Khalili, K. Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease. J. Cell. Physiol. 2019, 234, 8122–8133. [Google Scholar] [CrossRef] [PubMed]
- Pastore, A.; Piemonte, F. Protein glutathionylation in cardiovascular diseases. Int. J. Mol. Sci. 2013, 14, 20845–20876. [Google Scholar] [CrossRef] [PubMed]
- Lu, L.; Liu, M.; Sun, R.; Zheng, Y.; Zhang, P. Myocardial Infarction: Symptoms and Treatments. Cell Biochem. Biophys. 2015, 72, 865–867. [Google Scholar] [CrossRef]
- Eaton, P.; Wright, N.; Hearse, D.J.; Shattock, M.J. Glyceraldehyde phosphate dehydrogenase oxidation during cardiac ischemia and reperfusion. J. Mol. Cell. Cardiol. 2002, 34, 1549–1560. [Google Scholar] [CrossRef]
- Chen, F.C.; Ogut, O. Decline of contractility during ischemia-reperfusion injury: Actin glutathionylation and its effect on allosteric interaction with tropomyosin. Am. J. Physiol. Cell Physiol. 2006, 290, C719–C727. [Google Scholar] [CrossRef] [PubMed]
- Chen, Y.R.; Chen, C.L.; Pfeiffer, D.R.; Zweier, J.L. Mitochondrial complex II in the post-ischemic heart: Oxidative injury and the role of protein S-glutathionylation. J. Biol. Chem. 2007, 282, 32640–32654. [Google Scholar] [CrossRef]
- Avner, B.S.; Shioura, K.M.; Scruggs, S.B.; Grachoff, M.; Geenen, D.L.; Helseth, D.L., Jr.; Farjah, M.; Goldspink, P.H.; Solaro, R.J. Myocardial infarction in mice alters sarcomeric function via post-translational protein modification. Mol. Cell. Biochem. 2012, 363, 203–215. [Google Scholar] [CrossRef]
- Alegre-Cebollada, J.; Kosuri, P.; Giganti, D.; Eckels, E.; Rivas-Pardo, J.A.; Hamdani, N.; Warren, C.M.; Solaro, R.J.; Linke, W.A.; Fernández, J.M. S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cell 2014, 156, 1235–1246. [Google Scholar] [CrossRef] [PubMed]
- Chakouri, N.; Reboul, C.; Boulghobra, D.; Kleindienst, A.; Nottin, S.; Gayrard, S.; Roubille, F.; Matecki, S.; Lacampagne, A.; Cazorla, O. Stress-induced protein S-glutathionylation and phosphorylation crosstalk in cardiac sarcomeric proteins—Impact on heart function. Int. J. Cardiol. 2018, 258, 207–216. [Google Scholar] [CrossRef]
- Murry, C.E.; Jennings, R.B.; Reimer, K.A. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986, 74, 1124–1136. [Google Scholar] [CrossRef]
- Domenech, R.J.; Sánchez, G.; Donoso, P.; Parra, V.; Macho, P. Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: A mechanism for preconditioning? J. Mol. Cell. Cardiol. 2003, 35, 1429–1437. [Google Scholar] [CrossRef] [PubMed]
- Nikolaienko, R.; Bovo, E.; Zima, A.V. Redox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases. Front. Physiol. 2018, 9, 1775. [Google Scholar] [CrossRef]
- Sánchez, G.; Escobar, M.; Pedrozo, Z.; Macho, P.; Domenech, R.; Härtel, S.; Hidalgo, C.; Donoso, P. Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: Possible role in cardioprotection. Cardiovasc. Res. 2008, 77, 380–386. [Google Scholar] [CrossRef] [PubMed]
- Shimizu, I.; Minamino, T. Physiological and pathological cardiac hypertrophy. J. Mol. Cell. Cardiol. 2016, 97, 245–262. [Google Scholar] [CrossRef]
- Nakamura, M.; Sadoshima, J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat. Rev. Cardiol. 2018, 15, 387–407. [Google Scholar] [CrossRef]
- Bueno, O.F.; De Windt, L.J.; Tymitz, K.M.; Witt, S.A.; Kimball, T.R.; Klevitsky, R.; Hewett, T.E.; Jones, S.P.; Lefer, D.J.; Peng, C.F. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 2000, 19, 6341–6350. [Google Scholar] [CrossRef] [PubMed]
- Gallo, S.; Vitacolonna, A.; Bonzano, A.; Comoglio, P.; Crepaldi, T. ERK: A Key Player in the Pathophysiology of Cardiac Hypertrophy. Int. J. Mol. Sci. 2019, 20, 2164. [Google Scholar] [CrossRef] [PubMed]
- Pimentel, D.R.; Adachi, T.; Ido, Y.; Heibeck, T.; Jiang, B.; Lee, Y.; Melendez, J.A.; Cohen, R.A.; Colucci, W.S. Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation. J. Mol. Cell. Cardiol. 2006, 41, 613–622. [Google Scholar] [CrossRef]
- Adachi, T.; Pimentel, D.R.; Heibeck, T.; Hou, X.; Lee, Y.J.; Jiang, B.; Ido, Y.; Cohen, R.A. S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 2004, 279, 29857–29862. [Google Scholar] [CrossRef]
- Panieri, E.; Santoro, M.M. ROS homeostasis and metabolism: A dangerous liason in cancer cells. Cell Death Dis. 2016, 7, e2253. [Google Scholar] [CrossRef]
- Gorrini, C.; Harris, I.S.; Mak, T.W. Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 2013, 12, 931–947. [Google Scholar] [CrossRef]
- Garg, R.; Benedetti, L.G.; Abera, M.B.; Wang, H.; Abba, M.; Kazanietz, M.G. Protein kinase C and cancer: What we know and what we do not. Oncogene 2014, 33, 5225–5237. [Google Scholar] [CrossRef] [PubMed]
- Steinberg, S.F. Mechanisms for redox-regulation of protein kinase C. Front. Pharmacol. 2015, 6, 128. [Google Scholar] [CrossRef] [PubMed]
- Chu, F.; Ward, N.E.; O’Brian, C.A. PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon. Carcinogenesis 2003, 24, 317–325. [Google Scholar] [CrossRef][Green Version]
- Humphries, K.M.; Juliano, C.; Taylor, S.S. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J. Biol. Chem. 2002, 277, 43505–43511. [Google Scholar] [CrossRef]
- Humphries, K.M.; Deal, M.S.; Taylor, S.S. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J. Biol. Chem. 2005, 280, 2750–2758. [Google Scholar] [CrossRef] [PubMed]
- Cruz, C.M.; Rinna, A.; Forman, H.J.; Ventura, A.L.; Persechini, P.M.; Ojcius, D.M. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J. Biol. Chem. 2007, 282, 2871–2879. [Google Scholar] [CrossRef] [PubMed]
- Rao, R.K.; Clayton, L.W. Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation. Biochem. Biophys. Res. Commun. 2002, 293, 610–616. [Google Scholar] [CrossRef]
- Velu, C.S.; Niture, S.K.; Doneanu, C.E.; Pattabiraman, N.; Srivenugopal, K.S. Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress. Biochemistry 2007, 46, 7765–7780. [Google Scholar] [CrossRef]
- Pineda-Molina, E.; Klatt, P.; Vázquez, J.; Marina, A.; García de Lacoba, M.; Pérez-Sala, D.; Lamas, S. Glutathionylation of the p50 subunit of NF-kappaB: A mechanism for redox-induced inhibition of DNA binding. Biochemistry 2001, 40, 14134–14142. [Google Scholar] [CrossRef]
- Qanungo, S.; Starke, D.W.; Pai, H.V.; Mieyal, J.J.; Nieminen, A.L. Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB. J. Biol. Chem. 2007, 282, 18427–18436. [Google Scholar] [CrossRef]
- Butturini, E.; Darra, E.; Chiavegato, G.; Cellini, B.; Cozzolino, F.; Monti, M.; Pucci, P.; Dell’Orco, D.; Mariotto, S. S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation. ACS Chem. Biol. 2014, 9, 1885–1893. [Google Scholar] [CrossRef] [PubMed]
- Hensley, P.; Mishra, M.; Kyprianou, N. Targeting caspases in cancer therapeutics. Biol. Chem. 2013, 394, 831–843. [Google Scholar] [CrossRef] [PubMed]
- Zamaraev, A.V.; Kopeina, G.S.; Prokhorova, E.A.; Zhivotovsky, B.; Lavrik, I.N. Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation. Trends Cell Biol. 2017, 27, 322–339. [Google Scholar] [CrossRef] [PubMed]
- Boice, A.; Bouchier-Hayes, L. Targeting apoptotic caspases in cancer. Biochim. Biophys. Acta Mol. Cell Res. 2020, 1867, 118688. [Google Scholar] [CrossRef]
- Huang, Z.; Pinto, J.T.; Deng, H.; Richie, J.P., Jr. Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem. Pharmacol. 2008, 75, 2234–2244. [Google Scholar] [CrossRef]
- Pan, S.; Berk, B.C. Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: Key role for glutaredoxin in the death pathway. Circ. Res. 2007, 100, 213–219. [Google Scholar] [CrossRef]
- Musaogullari, A.; Mandato, A.; Chai, Y.-C. Role of Glutathione Depletion and Reactive Oxygen Species Generation of Caspase-3 Activation: A Study with the Kinase Inhibitor Staurosporine. Front. Physiol. 2020, 11, 998. [Google Scholar] [CrossRef]
- Byrne, C.D.; Targher, G. NAFLD: A multisystem disease. J. Hepatol. 2015, 62, S47–S64. [Google Scholar] [CrossRef]
- Friedman, S.L.; Neuschwander-Tetri, B.A.; Rinella, M.; Sanyal, A.J. Mechanisms of NAFLD development and therapeutic strategies. Nat. Med. 2018, 24, 908–922. [Google Scholar] [CrossRef]
- Videla, L.A.; Rodrigo, R.; Araya, J.; Poniachik, J. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol. Med. 2006, 12, 555–558. [Google Scholar] [CrossRef] [PubMed]
- Dou, X.; Li, S.; Hu, L.; Ding, L.; Ma, Y.; Ma, W.; Chai, H.; Song, Z. Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: A potential mechanism underlying non-alcoholic fatty liver disease. Exp. Mol. Med. 2018, 50, 7. [Google Scholar] [CrossRef] [PubMed]
- Rufini, A.; Tucci, P.; Celardo, I.; Melino, G. Senescence and aging: The critical roles of p53. Oncogene 2013, 32, 5129–5143. [Google Scholar] [CrossRef] [PubMed]
- Yu, J.; Zhang, L. PUMA, a potent killer with or without p53. Oncogene 2008, 27, S71–S83. [Google Scholar] [CrossRef] [PubMed]
- Deng, X.Q.; Chen, L.L.; Li, N.X. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. Liver Int. 2007, 27, 708–715. [Google Scholar] [CrossRef] [PubMed]
- Yin, H.; Hu, M.; Liang, X.; Ajmo, J.M.; Li, X.; Bataller, R.; You, M. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology 2014, 146, 801–811. [Google Scholar] [CrossRef]
- Seo, Y.Y.; Cho, Y.K.; Bae, J.C.; Seo, M.H.; Park, S.E.; Rhee, E.J.; Park, C.Y.; Oh, K.W.; Park, S.W.; Lee, W.Y. Tumor Necrosis Factor-α as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study. Endocrinol. Metab. 2013, 28, 41–45. [Google Scholar] [CrossRef]
- Kakino, S.; Ohki, T.; Nakayama, H.; Yuan, X.; Otabe, S.; Hashinaga, T.; Wada, N.; Kurita, Y.; Tanaka, K.; Hara, K.; et al. Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model. Horm. Metab. Res. 2018, 50, 80–87. [Google Scholar] [CrossRef]
- Hayden, M.S.; Ghosh, S. Regulation of NF-κB by TNF family cytokines. Semin. Immunol. 2014, 26, 253–266. [Google Scholar] [CrossRef]
- Solt, L.A.; May, M.J. The IkappaB kinase complex: Master regulator of NF-kappaB signaling. Immunol. Res. 2008, 42, 3–18. [Google Scholar] [CrossRef]
Protein | Reported Effect of S-Glutathionylation on Function | References |
---|---|---|
c-Jun | Inhibition | [52] |
Protein tyrosine phosphatase 1B (PTP1B) | Inhibition | [58] |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | Inhibition | [78] |
Estrogen receptor α | Inhibition | [92] |
AMP-activated protein kinase (AMPK) | Activation | [94] |
Sirtuin-1 | Inhibition | [112] |
Antigen 85C * | Inhibition | [113] |
Transcriptional Co-activator with PDZ-binding Motif (TAZ) | Activation | [114] |
Catalase | Inhibition | [115] |
Ryanodine receptor 2 (RyR2) | Activation | [116] |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Musaogullari, A.; Chai, Y.-C. Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease. Int. J. Mol. Sci. 2020, 21, 8113. https://doi.org/10.3390/ijms21218113
Musaogullari A, Chai Y-C. Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease. International Journal of Molecular Sciences. 2020; 21(21):8113. https://doi.org/10.3390/ijms21218113
Chicago/Turabian StyleMusaogullari, Aysenur, and Yuh-Cherng Chai. 2020. "Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease" International Journal of Molecular Sciences 21, no. 21: 8113. https://doi.org/10.3390/ijms21218113
APA StyleMusaogullari, A., & Chai, Y.-C. (2020). Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease. International Journal of Molecular Sciences, 21(21), 8113. https://doi.org/10.3390/ijms21218113