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Review

Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks

Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8018; https://doi.org/10.3390/ijms21218018
Received: 26 September 2020 / Revised: 25 October 2020 / Accepted: 26 October 2020 / Published: 28 October 2020
(This article belongs to the Section Molecular Oncology)
The Wnt pathway is an integral cell-to-cell signaling hub which regulates crucial development processes and maintenance of tissue homeostasis by coordinating cell proliferation, differentiation, cell polarity, cell movement, and stem cell renewal. When dysregulated, it is associated with various developmental diseases, fibrosis, and tumorigenesis. We now better appreciate the complexity and crosstalk of the Wnt pathway with other signaling cascades. Emerging roles of the Wnt signaling in the cancer stem cell niche and drug resistance have led to development of therapeutics specifically targeting various Wnt components, with some agents currently in clinical trials. This review highlights historical and recent findings on key mediators of Wnt signaling and how they impact antitumor immunity and maintenance of cancer stem cells. This review also examines current therapeutics being developed that modulate Wnt signaling in cancer and discusses potential shortcomings associated with available therapeutics. View Full-Text
Keywords: Wnt signaling; human diseases; cancer; antitumor immunity; cancer stemness; therapeutic strategies Wnt signaling; human diseases; cancer; antitumor immunity; cancer stemness; therapeutic strategies
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MDPI and ACS Style

Sharma, M.; Pruitt, K. Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks. Int. J. Mol. Sci. 2020, 21, 8018. https://doi.org/10.3390/ijms21218018

AMA Style

Sharma M, Pruitt K. Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks. International Journal of Molecular Sciences. 2020; 21(21):8018. https://doi.org/10.3390/ijms21218018

Chicago/Turabian Style

Sharma, Monica, and Kevin Pruitt. 2020. "Wnt Pathway: An Integral Hub for Developmental and Oncogenic Signaling Networks" International Journal of Molecular Sciences 21, no. 21: 8018. https://doi.org/10.3390/ijms21218018

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