Next Article in Journal
Candidatus Liberibacter Asiaticus’ SDE1 Effector Induces Huanglongbing Chlorosis by Downregulating Host DDX3 Gene
Next Article in Special Issue
Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis
Previous Article in Journal
Are Metal Ions That Make up Orthodontic Alloys Cytotoxic, and Do They Induce Oxidative Stress in a Yeast Cell Model?
Previous Article in Special Issue
α1AMP-Activated Protein Kinase Protects against Lipopolysaccharide-Induced Endothelial Barrier Disruption via Junctional Reinforcement and Activation of the p38 MAPK/HSP27 Pathway
Review

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease

1
Laboratory of Molecular and Metabolic Biochemistry, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000 Mons, Belgium
2
Molecular Physiology Research Unit (URPhyM), Namur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), 5000 Namur, Belgium
3
Division of Nephrology, Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7994; https://doi.org/10.3390/ijms21217994
Received: 2 October 2020 / Revised: 23 October 2020 / Accepted: 25 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue AMP-Activated Protein Kinase Signalling 2.0)
Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a significant public health problem associated with increased morbidity and mortality. CKD is associated with highly prevalent physiological and metabolic disturbances such as hypertension, obesity, insulin resistance, cardiovascular disease, and aging, which are also risk factors for CKD pathogenesis and progression. Podocytes and proximal tubular cells of the kidney strongly express AMP-activated protein kinase (AMPK). AMPK plays essential roles in glucose and lipid metabolism, cell survival, growth, and inflammation. Thus, metabolic disease-induced renal diseases like obesity-related and diabetic chronic kidney disease demonstrate dysregulated AMPK in the kidney. Activating AMPK ameliorates the pathological and phenotypical features of both diseases. As a metabolic sensor, AMPK regulates active tubular transport and helps renal cells to survive low energy states. AMPK also exerts a key role in mitochondrial homeostasis and is known to regulate autophagy in mammalian cells. While the nutrient-sensing role of AMPK is critical in determining the fate of renal cells, the role of AMPK in kidney autophagy and mitochondrial quality control leading to pathology in metabolic disease-related CKD is not very clear and needs further investigation. This review highlights the crucial role of AMPK in renal cell dysfunction associated with metabolic diseases and aims to expand therapeutic strategies by understanding the molecular and cellular processes underlying CKD. View Full-Text
Keywords: AMPK; chronic kidney disease; obesity; diabetes; autophagy; mitochondrial homeostasis; lipid metabolism; lipotoxicity; proximal tubule AMPK; chronic kidney disease; obesity; diabetes; autophagy; mitochondrial homeostasis; lipid metabolism; lipotoxicity; proximal tubule
Show Figures

Figure 1

MDPI and ACS Style

Juszczak, F.; Caron, N.; Mathew, A.V.; Declèves, A.-E. Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease. Int. J. Mol. Sci. 2020, 21, 7994. https://doi.org/10.3390/ijms21217994

AMA Style

Juszczak F, Caron N, Mathew AV, Declèves A-E. Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease. International Journal of Molecular Sciences. 2020; 21(21):7994. https://doi.org/10.3390/ijms21217994

Chicago/Turabian Style

Juszczak, Florian, Nathalie Caron, Anna V. Mathew, and Anne-Emilie Declèves. 2020. "Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease" International Journal of Molecular Sciences 21, no. 21: 7994. https://doi.org/10.3390/ijms21217994

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop